Application and prospect of natural active ingredients of traditional Chinese medicine in immunological adjuvant for influenza vaccine.
10.19540/j.cnki.cjcmm.20230823.602
- Author:
Yue ZHANG
1
;
Xiao-Lei LI
1
;
Hao-Yue LI
2
;
Xin-Xin WU
1
;
Yi-Zhi DONG
1
;
Jing ZHAO
1
Author Information
1. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences Beijing 100700, China.
2. International Cooperation Department, China Academy of Chinese Medical Sciences Beijing 100700, China.
- Publication Type:Journal Article
- Keywords:
immunological adjuvants;
influenza vaccine;
natural active ingredients;
traditional Chinese medicine
- MeSH:
Humans;
Influenza Vaccines;
Adjuvants, Immunologic/pharmacology*;
Medicine, Chinese Traditional;
Influenza, Human/prevention & control*;
Adjuvants, Pharmaceutic
- From:
China Journal of Chinese Materia Medica
2023;48(22):5985-5992
- CountryChina
- Language:Chinese
-
Abstract:
Vaccination is an effective method for preventing influenza, and adjuvants can enhance the immune response intensity and persistence of influenza vaccines. However, there are currently shortcomings in clinical adjuvant approvals, ineffectiveness against weak antigens, and a tendency to cause headaches. Therefore, the development of safe and effective novel adjuvants for influenza vaccines is particularly important to enhance vaccine immunogenicity and safety. Given the wide range of sources, high safety, and biodegradability of traditional Chinese medicine(TCM), some studies have described it as a vaccine adjuvant. This article reviewed the current status and challenges of influenza vaccine adjuvants, summarized the types of TCM adjuvants, the safety and immunomodulatory effects of natural active ingredients from TCM combined with influenza vaccines, the role of TCM adjuvants in antigen storage, antigen presentation capability, immune cells and cytokines, and immune responses, and analyzed the advantages and disadvantages of TCM adjuvants compared with small molecule adjuvants, with the aim of promoting the clinical development and commercialization of TCM adjuvants for influenza vaccines.
