Research progress on plant-derived exosome-like nanoparticles and their applications.
10.19540/j.cnki.cjcmm.20230721.602
- Author:
Lin-Si PAN
1
;
Wen-Cai WANG
2
;
Meng-Yu YAO
3
;
Xiao-Yan WANG
4
;
Xian-Zhi ZHANG
1
Author Information
1. College of Horticulture and Landscape Architecture, Zhongkai University of Agriculture and Engineering Guangzhou 510225, China.
2. Science and Technology Innovation Center, Guangzhou University of Chinese Medicine Guangzhou 510405, China.
3. Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Science,Southern Medical University Guangzhou 510000, China.
4. Doctor Workstation, Lianjiang People's Hospital Affiliated to Guangdong Medical University Zhanjiang 524400, China.
- Publication Type:Journal Article
- Keywords:
cross-regulation;
exosome;
medical application;
plant-derived exosome-like nanoparticles;
separation and characterization
- MeSH:
Animals;
Exosomes/metabolism*;
Proteins/metabolism*;
Plants/metabolism*;
Nucleic Acids;
Nanoparticles
- From:
China Journal of Chinese Materia Medica
2023;48(22):5977-5984
- CountryChina
- Language:Chinese
-
Abstract:
Plant-derived exosome-like nanoparticles(PELNs) are a class of membranous vesicles with diameters approximately ranging from 30 to 300 nm, isolated from plant tissues. They contain components such as proteins, lipids, and nucleic acids. PELNs play an important role in the metabolism of plant substances and immune defense, and can also cross-regulate the physiological activities of fungi and animal cells, showing significant potential applications. In recent years, research on PELNs has significantly increased, highlighting three main issues:(1) the mixed sources of plant materials for PELNs;(2) the lack of a unified system for isolating and characterizing PELNs;(3) the urgent need to elucidate the molecular mechanisms underlying the cross-regulation of biological functions by PELNs. This article focused on these concerns. It began by summarizing the biological origin and composition of PELNs, discussing the techniques for isolating and characterizing PELNs, and analyzing their biomedical applications and potential future research directions., aiming to promote the establishment of standardized research protocols for PELNs and provide theoretical references for in-depth exploration of the mechanisms underlying PELNs' cross-regulatory effects.
