Comparison of distribution of eight components from Liangxue Tuizi Mixture between normal and Henoch-Schonlein purpura rats.
10.19540/j.cnki.cjcmm.20230618.202
- Author:
Li-Ling SI
1
;
Lu NIU
2
;
Xiao-Yan WANG
3
;
Hui ZHANG
2
;
Ming-Liang ZHANG
2
;
Shuang XU
4
;
Xian-Qing REN
4
;
Jin-Fa TANG
3
;
Wei-Xia LI
3
Author Information
1. School of Pharmacy, Henan University of Chinese Medicine Zhengzhou 450046, China the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450000, China.
2. the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450000, China.
3. the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450000, China Henan Province Engineering Research Center of Clinical Application, Evaluation and Transformation of Traditional Chinese Medicine,Henan Province Engineering Research Center of Safety Evaluation and Risk Management of Traditional Chinese Medicine,Henan Provincial Key Laboratory for Clinical Pharmacy of Traditional Chinese Medicine Zhengzhou 450000, China.
4. the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450000, China School of Pediatrics, Henan University of Chinese Medicine Zhengzhou 450046, China.
- Publication Type:Journal Article
- Keywords:
Henoch-Schonlein purpura;
Liangxue Tuizi Mixture;
UPLC-TQ-MS;
tissue distribution
- MeSH:
Rats;
Animals;
IgA Vasculitis/drug therapy*;
Monoterpenes;
Administration, Oral;
Liquid Chromatography-Mass Spectrometry
- From:
China Journal of Chinese Materia Medica
2023;48(21):5915-5931
- CountryChina
- Language:Chinese
-
Abstract:
This study used UPLC-TQ-MS technology to replicate a Henoch-Schonlein purpura(HSP) model in rats by administering warm drugs by gavage and injecting ovalbumin with Freund's complete adjuvant emulsion. The distribution differences and characteristics of eight major components(ferulic acid, caffeic acid, neochlorogenic acid, cryptochlorogenic acid, benzoyl oxypaeoniflorin, tracheloside, loganin, and paeoniflorin) in rat liver, lung, heart, spleen, and kidney tissues were determined after oral administration of the Liangxue Tuizi Mixture at a dose of 42 g·kg~(-1) in both normal physiological and HSP states at 0.5, 1, 2, 6, and 12 hours. The results showed that the distribution patterns of the eight components of Liangxue Tuizi Mixture in the tissues of normal and HSP model rats were different. The main component, paeoniflorin, in Moutan Cortex and Paeoniae Radix Alba had higher content in all tissues. The eight components were predominantly distributed in the liver, lung, and kidney tissues, followed by spleen and heart tissues.
