A new xanthone from hulls of Garcinia mangostana and its cytotoxic activity.
10.19540/j.cnki.cjcmm.20230805.201
- Author:
Feng-Ning ZHAO
1
;
Qi NIU
2
;
Die XIAO
2
;
Hao-Nan XU
2
;
Hao-Xin WANG
2
;
Rong-Lu BI
1
;
Hong-Ping HE
2
;
Zhi-Yong JIANG
2
Author Information
1. Chuxiong Yunzhi Pharmaceutical Co., Ltd. Chuxiong 675005, China.
2. Key Laboratory of Modern Research on Ethnic Medicine in Yunnan Provincial Universities, Ethnomedicine School,Yunnan University of Chinese Medicine Kunming 650500, China.
- Publication Type:Journal Article
- Keywords:
Garcinia mangostana;
Guttiferae;
cytotoxicity;
xanthone
- MeSH:
Humans;
Garcinia mangostana/chemistry*;
HeLa Cells;
Antineoplastic Agents;
Magnetic Resonance Spectroscopy;
Xanthones/pharmacology*;
Garcinia/chemistry*;
Plant Extracts/chemistry*;
Molecular Structure
- From:
China Journal of Chinese Materia Medica
2023;48(21):5817-5821
- CountryChina
- Language:Chinese
-
Abstract:
Eight compounds were isolated from ethyl acetate fraction of 80% ethanol extract of the hulls of Garcinia mangostana by silica gel, Sephadex LH-20 column chromatography, as well as prep-HPLC methods. By HR-ESI-MS, MS, 1D and 2D NMR spectral analyses, the structures of the eight compounds were identified as 16-en mangostenone E(1), α-mangostin(2), 1,7-dihydroxy-2-(3-methy-lbut-2-enyl)-3-methoxyxanthone(3), cratoxyxanthone(4), 2,6-dimethoxy-para-benzoquinone(5), methyl orselinate(6), ficusol(7), and 4-(4-carboxy-2-methoxyphenoxy)-3,5-dimethoxybenzoic acid(8). Compound 1 was a new xanthone, and compound 4 was a xanthone dimer, compound 5 was a naphthoquinone. All compounds were isolated from this plant for the first time except compounds 2 and 3. Cytotoxic bioassay suggested that compounds 1, 2 and 4 possessed moderate cytotoxicity, suppressing HeLa cell line with IC_(50) va-lues of 24.3, 35.5 and 17.1 μmol·L~(-1), respectively. Compound 4 also could suppress K562 cells with an IC_(50) value of 39.8 μmol·L~(-1).
