Two new phenylpropanoids from wine-processed Corni Fructus.
10.19540/j.cnki.cjcmm.20230616.204
- Author:
Jing WANG
1
;
Jun CHI
1
;
Pei WANG
1
;
Bin CAO
1
;
Ling-Xia ZHANG
1
;
Zhi-Min WANG
2
;
Li-Ping DAI
1
Author Information
1. Henan University of Chinese Medicine Zhengzhou 450046, China Engineering Technology Research Center for Comprehensive Development and Utilization of Authentic Medicinal Materials in Henan Province, Henan University of Chinese Medicine Zhengzhou 450046, China.
2. Engineering Technology Research Center for Comprehensive Development and Utilization of Authentic Medicinal Materials in Henan Province, Henan University of Chinese Medicine Zhengzhou 450046, China National Engineering Laboratory for Quality Control Technology of Chinese Herbal Medicines, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
- Publication Type:Journal Article
- Keywords:
biological activities;
chemical constituents;
phenylpropanols;
wine-processed Corni Fructus
- MeSH:
Cornus;
Wine;
Naphthols;
Lignin
- From:
China Journal of Chinese Materia Medica
2023;48(21):5809-5816
- CountryChina
- Language:Chinese
-
Abstract:
Six compounds were isolated from aqueous extract of wine-processed Corni Fructus through silica gel, ODS column chromatography, Sephadex LH-20 gel column chromatography, reverse phase preparative HPLC and other chromatographic separation technologies. Their structures were identified with multiple spectroscopical methods including HR-ESI-MS, UV, IR, NMR and ECD and so on. Their structures were established as pinoresinoside B(1), cornusgallicacid A(2),(+)-isolariciresinol-9'-O-β-glucopyranoside(3),(-)-isolariciresinol 3α-O-β-D-glucopyranoside(4),(7R,8S)-dihydrodehydrodiconiferyl alcohol 9-O-β-D-glucopyranoside(5), and(-)-seco isolariciresinol-9'-O-β-D-glucopyranoside(6). Among them, compounds 1 and 2 were two new compounds. The biological activity evaluation results showed that compounds 2 and 6 had strong DPPH free radical scavenging ability, with EC_(50) values of(4.18±1.96) and(21.45±1.19) μmol·L~(-1), respectively. Compounds 1 and 2 had protective effects on H_2O_2-induced oxidative damage in NRK-52E cells in a dose-dependent manner, and the cell survival rate of compound 2 at 100 μmol·L~(-1) was 96.09%±1.77%.
