Research progress on natural guaiane-type sesquiterpenoids and their biological activities.
10.19540/j.cnki.cjcmm.20230731.301
- Author:
Jie GUO
1
;
Jia-Ping WANG
1
;
Bo PENG
1
;
Xiao-Qian LIU
1
;
Chen-Xi YANG
1
;
Li-Hua YAN
1
;
Zhi-Min WANG
1
Author Information
1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
- Publication Type:Journal Article
- Keywords:
anti-inflammatory activity;
antibacterial activity;
antitumor activity;
guaiane-type sesquiterpenoids;
neuroprotective activity
- MeSH:
Humans;
Molecular Structure;
Sesquiterpenes, Guaiane;
Asteraceae/chemistry*;
Sesquiterpenes
- From:
China Journal of Chinese Materia Medica
2023;48(21):5727-5749
- CountryChina
- Language:Chinese
-
Abstract:
Guaiane-type sesquiterpenoids are a class of terpenoids with [5,7] ring-fused system as the basic skeletal structure composed of three isoprene units, which are substituted by 4,10-dimethyl-7-isopropyl. According to the difference in functional groups and degree of polymerization, they can be divided into simple guaiane-type sesquiterpenoids, sesquiterpene lactones, sesquiterpene dimers, and sesquiterpene trimers. Natural guaiane-type sesquiterpenoids are widely distributed in plants, fungi, and marine organisms, especially in families such as Compositae, Zingiberaceae, Thymelaeaceae, Lamiaceae, and Alismataceae. Guaiane-type sesquiterpenoids have good antibacterial, anti-inflammatory, anticancer, and neuroprotective effects. In this paper, the novel guaiane-type sesquiterpenoids isolated and identified in recent 10 years(2013-2022) and their biological activities were reviewed in order to provide refe-rences for the research and development of guaiane-type sesquiterpenoids.
