A Case of Hydroxyzine Induced Torsades de Pointes.
10.4070/kcj.1998.28.6.1011
- Author:
Jin Wuk KWON
1
;
Woong Chol KANG
;
Moon Hyoung LEE
;
Shin Ki AHN
;
Sung Soon KIM
Author Information
1. Cardiology Division, Yonsei Cardiovascular Center, Yonsei University, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Torsades de pointes;
Antihistamine
- MeSH:
Adult;
Astemizole;
Drug Overdose;
Histamine Antagonists;
Humans;
Hydroxyzine*;
Isoproterenol;
Liver Diseases;
Male;
Tachycardia, Ventricular;
Terfenadine;
Torsades de Pointes*
- From:Korean Circulation Journal
1998;28(6):1011-1016
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Torsades de pointes is a polymorphic ventricular tachycardia associated with prolonged QT interval and increased U wave amplitude. It has been found to be induced by various drugs, electrolyte imbalances, and so on, but the mechanism of torsades de pointes has not been completely documented. Two hypotheses, early afterdepolarization and dispersion of repolarization have been known to be the possible mechanism. Terfenadine and astemizole are the antihistamines, known to be one of the etiologic agents of torsades de pointes, and factors associated with increased risk are significant liver disease, drug overdose, and concomitant administration of imidazole and macrolide antimicrobial drugs. There has been only one case reported that torsades de pointes had been induced by first-generation antihistamine, piprinhydrinate. We experienced a case of 43 year old male patient with torsades de pointes induced by first-generation antihistamine, hydroxyzine and treated successfully with drug cessation, MgSO
