Molecular mechanism of sleep deprivation-induced body injury and traditional Chinese medicine prevention and treatment: a review.
10.19540/j.cnki.cjcmm.20230710.703
- Author:
Dan YANG
1
;
Yan SHI
1
;
Yi-Xuan WANG
2
;
Qian KANG
1
;
Ming-Hui XIU
3
;
Jian-Zheng HE
4
Author Information
1. Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and Study on Prevention and Treatment of Traditional Chinese Medicine, Gansu University of Chinese Medicine Lanzhou 730000,China School of Basic Medicine, Gansu University of Chinese Medicine Lanzhou 730000,China.
2. School of Public Health,Gansu University of Chinese Medicine Lanzhou 730000,China.
3. Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and Study on Prevention and Treatment of Traditional Chinese Medicine, Gansu University of Chinese Medicine Lanzhou 730000,China Key Laboratory of Dunhuang Medicine, Ministry of Education, Gansu University of Chinese medicine Lanzhou 730000,China School of Public Health,Gansu University of Chinese Medicine Lanzhou 730000,China.
4. Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and Study on Prevention and Treatment of Traditional Chinese Medicine, Gansu University of Chinese Medicine Lanzhou 730000,China Key Laboratory of Dunhuang Medicine, Ministry of Education, Gansu University of Chinese medicine Lanzhou 730000,China School of Basic Medicine, Gansu University of Chinese Medicine Lanzhou 730000,China.
- Publication Type:Journal Article
- Keywords:
brain;
gut;
inflammation;
oxidative stress;
sleep deprivation;
traditional Chinese medicine
- MeSH:
Humans;
Medicine, Chinese Traditional;
Sleep Deprivation/drug therapy*;
Sleepiness;
Yin-Yang;
China;
Drugs, Chinese Herbal/therapeutic use*
- From:
China Journal of Chinese Materia Medica
2023;48(21):5707-5718
- CountryChina
- Language:Chinese
-
Abstract:
Sleep occupies one-third of a person's lifetime and is a necessary condition for maintaining physiological function and health. With the increase in social and economic pressures, the growing use of electronic devices and the accelerated aging process of the population, insufficient sleep and its hazards have drawn widespread attention from researchers in China and abroad. Sleep deprivation refers to a decrease in sleep or a severe lack of sleep due to various reasons. Previous studies have found that sleep deprivation can cause extensive damage to the body, including an increased incidence and mortality rate of neuropathic diseases in the brain, cardiovascular diseases, imbalances in the gut microbiota, and other multi-organ diseases. The mechanisms underlying the occurrence of multi-system and multi-organ diseases due to sleep deprivation mainly involve oxidative stress, inflammatory responses, and impaired immune function in the body. According to traditional Chinese medicine(TCM), sleep deprivation falls into the category of sleepiness, and long-term sleepiness leads to Yin-Yang imbalance, resulting in the consumption of Qi and damage to the five Zang-organs. The appropriate treatment should focus on tonifying deficiency, reinforcing healthy Qi, and harmonizing Yin and Yang. TCM is characterized by a wide variety and abundant resources, and it has minimal side effects and a broad range of applications. Numerous studies have shown that TCM drugs and prescriptions not only improve sleep but also have beneficial effects on liver nourishment, intelligence enhancement, and kidney tonification, effectively preventing and treating the body injury caused by sleep deprivation. Given the increasing prevalence of sleep deprivation and its significant impact on body health, this article reviewed sleep deprivation-mediated body injury and its mechanism, summarized and categorized TCM compound prescriptions and single drugs for preventing and treating body injury, with the aim of laying the foundation for researchers to develop effective drugs for preventing and treating body injury caused by sleep deprivation and providing references for further exploration of the molecular mechanisms underlying the body injury caused by sleep deprivation.
