Research progress on Rhododendron molle in treatment of rheumatoid arthritis.
10.19540/j.cnki.cjcmm.20230811.601
- Author:
Wen-Ya MEI
1
;
Xiang-Dan LIU
2
;
Zhi-Hui WANG
3
;
Jun-Bao YU
1
;
Jia-Wei HE
1
;
Jing-Yu ZHANG
1
;
Ri-Bao ZHOU
2
;
Xiao-Rong LIU
3
Author Information
1. School of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China.
2. School of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China Key Research Laboratory of Germplasm Resources and Standardized Planting of Genuine Regional Medicinal Materials Produced in Hunan Province Changsha 410208, China Key Laboratory of Modern Research of Traditional Chinese Medicine, Education Department of Hunan Province Changsha 410208, China.
3. School of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China Key Research Laboratory of Germplasm Resources and Standardized Planting of Genuine Regional Medicinal Materials Produced in Hunan Province Changsha 410208, China.
- Publication Type:Journal Article
- Keywords:
Rhododendron molle;
action mechanism;
diterpenoids;
rheumatoid arthritis;
rhodojaponin-Ⅲ
- MeSH:
Humans;
Rhododendron/chemistry*;
Arthritis, Rheumatoid/drug therapy*;
Anti-Inflammatory Agents;
Diterpenes/pharmacology*;
Analgesics
- From:
China Journal of Chinese Materia Medica
2023;48(21):5690-5700
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis(RA), as a chronic autoimmune disease, has a high incidence and disability rate, causing significant suffering to patients. Due to its complex pathogenesis, it has not been fully elucidated to date, and its treatment remains a challenging problem in the medical field. Although western medicine treatment options have certain efficacy, they require prolonged use and are expensive. Additionally, they carry risks of multiple infections and adverse reactions like malignancies. The Chinese herbal medicine Rhododendron molle is commonly used in folk medicine for its properties of dispelling wind, removing dampness, calming nerves, and alleviating pain in the treatment of diseases like rheumatic bone diseases. In recent years, modern clinical and pharmacological studies have shown that the diterpenoids in R. molle are effective components, exhibiting immune-regulatory, anti-inflammatory, and analgesic effects. This makes it a promising candidate for treating RA with a broad range of potential applications. However, R. molle has certain toxic properties that hinder its clinical application and lead to the wastage of its resources. This study reviewed recent research progress on the mechanism of R. molle in preventing and treating RA, focusing on its chemical components, anti-inflammatory and analgesic properties and summarized the adverse reactions associated with R. molle, aiming to offer new ideas for finding natural remedies for RA and methods to reduce toxicity while enhancing the effectiveness of R. molle. The study seeks to clarify the safety and efficacy of R. molle and its extracts, providing a theoretical basis for its application prospects and further promoting the development and utilization of R. molle resources.
