Research progress on Huangqi Guizhi Wuwu Decoction and predictive analysis of quality markers.
10.19540/j.cnki.cjcmm.20230516.201
- Author:
Guang-Ying LU
1
;
Jia-Yun WANG
2
;
Zu GAO
2
;
Ke MA
1
;
Hua-Yun YU
1
;
Shi-Jun WANG
1
Author Information
1. Shandong University of Traditional Chinese Medicine Ji'nan 250355, China Shandong Co-Innovation Center of Classic TCM Formula Ji'nan 250355, China.
2. Shandong University of Traditional Chinese Medicine Ji'nan 250355, China.
- Publication Type:Journal Article
- Keywords:
Huangqi Guizhi Wuwu Decoction;
chemical composition;
clinical application;
pharmacological effect;
quality markers
- MeSH:
Drugs, Chinese Herbal/therapeutic use*;
Medicine, Chinese Traditional;
Astragalus propinquus;
Frostbite/drug therapy*
- From:
China Journal of Chinese Materia Medica
2023;48(20):5438-5449
- CountryChina
- Language:Chinese
-
Abstract:
Huangqi Guizhi Wuwu Decoction is a classic prescription in traditional Chinese medicine(TCM) and is known for its effects of tonifying Qi, warming the meridians, and promoting blood circulation to alleviate obstruction. It is primarily used to treat conditions characterized by Qi stagnation, Yang deficiency, and obstruction, and it exhibits pharmacological effects such as immune regulation, anti-inflammation, analgesia, protection of the cardiovascular and cerebrovascular systems, itch relief, reduction of frostbite symptoms, antioxidative stress, promotion of cell apoptosis, and kidney protection. In modern clinical practice, it is commonly used to treat acute myocardial infarction, sequelae of cerebral infarction, cervical spondylosis, frozen shoulder, lower limb arteriosclerosis, lower limb vascular disorders, peripheral neuropathy in diabetes, and lupus nephritis. Recent research has focused on the chemical components, pharmacological effects, and clinical applications of Huangqi Guizhi Wuwu Decoction. Based on the "five principles" of quality markers(Q-markers) in TCM, this study predicted and analyzed the Q-markers of Huangqi Guizhi Wuwu Decoction. It suggested that astragaloside Ⅳ, formononetin, kaempferol, quercetin, cinnamic acid, cinnamaldehyde, 6-gingerol, paeoniflorin, albiflorin, and gallic acid could serve as Q-markers for Huangqi Guizhi Wuwu Decoction. The findings of this study can provide references for quality control of Huangqi Guizhi Wuwu Decoction and the development of new Chinese medicinal formulations.
