Three new diterpenoids from whole herb of Carpesium cernuum.
10.19540/j.cnki.cjcmm.20230713.201
- Author:
Shu-Hui FENG
1
;
Wei-Qing ZHANG
2
;
Wei LIANG
2
;
Chen YAN
2
Author Information
1. People's Hospital of Anshun City Anshun 561000, China Guizhou University of Traditional Chinese Medicine Guiyang 550002, China.
2. People's Hospital of Anshun City Anshun 561000, China.
- Publication Type:Journal Article
- Keywords:
Carpesium cernuum;
chemical constituent;
cytotoxicity activity;
diterpenoid;
structural identification
- MeSH:
Humans;
Asteraceae/chemistry*;
MCF-7 Cells;
Magnetic Resonance Spectroscopy;
Chromatography, High Pressure Liquid;
A549 Cells
- From:
China Journal of Chinese Materia Medica
2023;48(19):5244-5249
- CountryChina
- Language:Chinese
-
Abstract:
The study investigated the chemical constituents from the whole herb of Carpesium cernuum. Three new diterpenoids were isolated from the whole herb of C. cernuum by column chromatography on silica gel, Sephadex LH-20, and semi-preparative HPLC. Their structures were identified by MS, NMR and other spectral techniques. The isolates were identified as(5Z)-2-oxo-2, 10, 14-trimethylhexadeca-5, 13-diene-11α, 18-diol(1),(2E, 10E)-7-[(acetyloxy)methyl]-3, 11, 15-trimethylhexadeca-2, 10, 14-triene-1, 12α-diol(2),(2E, 6Z)-3, 11, 15-trimethylhexadeca-2, 6, 14-triene-1, 12α, 19-triol(3), respectively. The cytotoxic activity of compounds 1-3 were investigated with DU-145, MCF-7, and A549 cells by MTT. The results showed that compound 1 and 3 had certain inhibitory effects on MCF-7 cells, with the inhibition rates of 45.06% and 29.40%, respectively.
