Potential targets for traditional Chinese medicine treatment of chronic inflammation in obesity: macrophage polarization.
10.19540/j.cnki.cjcmm.20230619.602
- Author:
Ji-Xin LI
1
;
Lin-Jie QIU
1
;
Yan REN
1
;
Wen-Ru WANG
1
;
Zhen-Yu YANG
2
;
Mei-Jie LI
1
;
Jin ZHANG
1
Author Information
1. Xiyuan Hospital, China Academy of Chinese Medical Sciences Beijing 100091, China.
2. Heilongjiang University of Chinese Medicine Harbin 150040, China.
- Publication Type:Journal Article
- Keywords:
inflammation;
macrophage polarization;
mechanism;
obesity;
traditional Chinese medicine
- MeSH:
Humans;
Animals;
Mice;
Medicine, Chinese Traditional;
Obesity/drug therapy*;
Adipose Tissue/pathology*;
Inflammation/drug therapy*;
Macrophages;
Mice, Inbred C57BL
- From:
China Journal of Chinese Materia Medica
2023;48(19):5113-5121
- CountryChina
- Language:Chinese
-
Abstract:
Obesity has been identified as a chronic low-grade systemic inflammation and a key risk factor for diseases such as diabetes, hypertension, and malignancies, and has become an urgent global health burden. Adipose tissue macrophages play a significant role in adipose immune homeostasis and inflammatory responses. Under different conditions, they can be polarized into pro-inflammatory M1 phenotype or anti-inflammatory M2 phenotype. In obese individuals, there is abnormal polarization of macrophages in adipose tissue, leading to an imbalance in the M1/M2 phenotype dynamic equilibrium and the development of pathological inflammation. Therefore, restoring the balance of M1/M2 macrophage polarization is an important potential target for the treatment of chronic inflammation in obesity. Studies have shown that traditional Chinese medicine(TCM) can positively modulate macrophage polarization and produce beneficial effects on obesity. Based on existing evidence, this paper systematically reviewed the potential mechanisms of TCM in improving chronic inflammation in obesity from the perspective of macrophage polarization, in order to provide evidence for the clinical diagnosis and treatment of chronic inflammation in obesity with TCM and offer new insights for related research design and the development of new TCM.
