Isolation and identification of chemical constituents from aerial parts of Glycyrrhiza uralensis.
10.19540/j.cnki.cjcmm.20230427.202
- Author:
Guan-Hua CHANG
1
;
Lu ZHANG
2
;
Jie CUI
3
;
Wen-Quan WANG
4
;
Jun-Ling HOU
5
Author Information
1. Beijing Wehand-Bio Pharmaceutical Co.,Ltd. Beijing 102629,China School of Chinese Materia Medica,Beijing University of Chinese Medicine Beijing 102488,China.
2. School of Chinese Materia Medica,Beijing University of Chinese Medicine Beijing 102488,China.
3. Institute of Medicinal Plant Development,Chinese Academy of Medicinal Sciences and Peking Union Medical College Beijing 100193,China.
4. School of Chinese Materia Medica,Beijing University of Chinese Medicine Beijing 102488,China Institute of Medicinal Plant Development,Chinese Academy of Medicinal Sciences and Peking Union Medical College Beijing 100193,China Engineering Research Center of Good Agricultural Practice for Chinese Crude Drugs,Ministry of Education Beijing 100102,China.
5. School of Chinese Materia Medica,Beijing University of Chinese Medicine Beijing 102488,China Engineering Research Center of Good Agricultural Practice for Chinese Crude Drugs,Ministry of Education Beijing 100102,China.
- Publication Type:Journal Article
- Keywords:
Glycyrrhiza uralensis;
chemical constituents;
flavonoids;
isolation and determination
- MeSH:
Glycyrrhiza uralensis/chemistry*;
Plant Components, Aerial/chemistry*
- From:
China Journal of Chinese Materia Medica
2023;48(16):4413-4420
- CountryChina
- Language:Chinese
-
Abstract:
The present study investigated the chemical constituents from the aerial parts of Glycyrrhiza uralensis. The ethanol extract of the aerial parts of G. uralensis was separated and purified by different column chromatographies such as macroporous resin, silica gel, and Sephadex LH-20, and through preparative HPLC and recrystallization. Thirteen compounds were isolated and identified as(2S)-6-[(Z)-3-hydroxymethyl-2-butenyl]-5,7,3'-trihydroxy-4'-methoxy-dihydroflavanone(1),(2S)-8-[(E)-3-hydroxymethyl-2-butenyl]-5,7,3',5'-tetrahydroxy-dihydroflavanone(2), α,α'-dihydro-5,4'-dihydroxy-3-acetoxy-2-isopentenylstilbene(3), 6-prenylquercetin(4), 6-prenylquercetin-3-methyl ether(5), formononetin(6), 3,3'-dimethylquercetin(7), chrysoeriol(8), diosmetin(9),(10E,12Z,14E)-9,16-dioxooctadec-10,12,14-trienoic acid(10), 5,7,3',4'-tetrahydroxy-6-prenyl-dihydroflavanone(11), naringenin(12), dibutylphthalate(13). Compounds 1-3 are new compounds, and compounds 10 and 13 are isolated from aerial parts of this plant for the first time.
