Research progress in pathogenesis and traditional Chinese medicines treatment of ischemic stroke-related headache.
10.19540/j.cnki.cjcmm.20230506.601
- Author:
Yu-Meng PENG
1
;
Jun-Qi WANG
2
;
Ying-Lu BAI
2
;
Yan WANG
2
;
Rao FU
2
;
Yi-Yu LIU
3
;
Zhi-Yong LI
4
;
Xiu-Lan HUANG
2
Author Information
1. School of Pharmacy,Minzu University of China Beijing 100081,China Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China.
2. School of Pharmacy,Minzu University of China Beijing 100081,China.
3. School of Basic Medicine,Shanxi University of Chinese Medicine Jinzhong 030619,China.
4. Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China.
- Publication Type:Journal Article
- Keywords:
active ingredient of traditional Chinese medicines;
headache;
ischemic stroke;
research progress
- MeSH:
Humans;
Ischemic Stroke/drug therapy*;
Brain Ischemia/drug therapy*;
Medicine, Chinese Traditional;
Stroke/drug therapy*;
Headache/drug therapy*;
Drugs, Chinese Herbal/therapeutic use*
- From:
China Journal of Chinese Materia Medica
2023;48(16):4261-4274
- CountryChina
- Language:Chinese
-
Abstract:
Headache is a common clinical complication of ischemic stroke. As a precursor of stroke, headache occurs repeatedly in the convalescent period of ischemic stroke, leading to secondary stroke and seriously hindering patients' rehabilitation. Currently, it is believed that the pathogenesis of ischemic stroke-related headache is associated with the abnormal release of vasoactive substances, high platelet aggregation, and stimulation of intracranial pain-sensitive structures. The active ingredients in traditional Chinese medicines(TCM) with the effects of activating blood to resolve stasis and clearing heat to release exterior can protect brain tissue and relieve headache by reducing the release of inflammatory cytokines, alleviating antioxidant stress, inhibiting neuronal apoptosis and so on. This paper introduces the research progress in the potential mechanism and TCM treatment of ischemic stroke-related headache, aiming to provide reference for further research and drug development of this complication.
