Q-marker prediction of resin ethanol extract of Gegen Qinlian Decoction based on characteristic spectrum and network pharmacology.
10.19540/j.cnki.cjcmm.20230518.303
- Author:
Xiao-Qin YANG
1
;
Shu-Yang WU
1
;
Min LI
1
;
Jia-Mei CHEN
1
;
Yan-Fen CHENG
1
;
Yi-Tao WANG
2
;
Yi-Han WU
1
;
Jin-Ming ZHANG
1
Author Information
1. State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China.
2. State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China State Key Laboratory of Quality Research in Traditional Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau Macau 999078, China.
- Publication Type:Journal Article
- Keywords:
Gegen Qinlian Decoction;
characteristic spectrum;
ethanol extract of macroporous resin;
network pharmacology;
qua-lity markers
- MeSH:
Irinotecan;
Network Pharmacology;
Drugs, Chinese Herbal/therapeutic use*
- From:
China Journal of Chinese Materia Medica
2023;48(18):4993-5002
- CountryChina
- Language:Chinese
-
Abstract:
The resin ethanol extract of Gegen Qinlian Decoction(GGQLD) has been found to significantly alleviate the intestinal toxicity caused by Irinotecan, but further research is needed to establish its overall quality and clinical medication standards. This study aimed to establish an HPLC characteristic fingerprint of the resin ethanol extract of GGQLD, predicted the targets and signaling pathways of its pharmacological effects based on network pharmacology, identified core compounds with pharmacological relevance, and analyzed potential quality markers(Q-markers) of the resin eluate of GGQLD for relieving Irinotecan-induced toxicity. By considering the uniqueness, measurability, and traceability of Q-markers based on the "five principles" of Q-markers and combining them with network pharmacology techniques, the overall efficacy of the resin ethanol extract of GGQLD can be characterized. Preliminary predictions suggested that the four components of puerarin, berberine, baicalin, and baicalein might serve as potential Q-markers for the resin etha-nol extract of GGQLD. This study provides a basis and references for the quality control and clinical mechanism of the resin ethanol extract of GGQLD.
