Research progress in gut-skin axis and its association with traditional Chinese medicine theory.
10.19540/j.cnki.cjcmm.20230517.301
- Author:
Yong-Mei GUAN
1
;
Shi-Chun ZHAO
1
;
Qiong LI
2
;
Li-Hua CHEN
1
;
Fei WANG
2
;
Huan-Huan DONG
2
;
Fang WANG
1
;
Xiao-Fan CHEN
3
;
Hua ZHANG
2
;
Wei-Feng ZHU
1
Author Information
1. Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine Nanchang 330004, China.
2. School of Pharmacy, Jiangxi University of Chinese Medicine Nanchang 330004, China.
3. School of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine Nanchang 330004, China.
- Publication Type:Journal Article
- Keywords:
acne vulgaris;
atopic dermatitis;
external treatment of intestinal diseases;
gut barrier;
gut-skin axis;
internal treatment of skin diseases;
psoriasis;
skin barrier
- MeSH:
Humans;
Medicine, Chinese Traditional;
Gastrointestinal Tract;
Skin Diseases/drug therapy*;
Gastrointestinal Microbiome
- From:
China Journal of Chinese Materia Medica
2023;48(18):4908-4918
- CountryChina
- Language:Chinese
-
Abstract:
Currently, the gut-organ axis has become a hot research topic. As increasing attention has been paid to the role of gut microbiota in the health of organs, the complex and integrated dialogue mechanism between the gastrointestinal tract and the associated microbiota has been demonstrated in more and more studies. Skin as the largest organ in the human body serves as the primary barrier protecting the human body from damage. The proposal of the gut-skin axis has established a bidirectional link between the gut and the skin. The disturbance of gut microbiota can lead to the occurrence of skin diseases, the mechanism of which is complex and may involve multiple pathways in immunity, metabolism, and internal secretion. According to the theory of traditional Chinese medicine(TCM), the connection between the intestine and the skin can be established through the lung, and the interior disorders will definitely cause symptoms on the exterior. This paper reviews the research progress in the gut-skin axis and its correlation with TCM theory and provides ideas and a basis for cli-nical treatment and drug development of skin and intestinal diseases.
