Study of the Relation between Rreduced E-cadherin Expression and Known Prognostic Factors in Breast Cancer.
- Author:
Jin Woo RYU
1
;
Min CHUNG
;
Jeong Taek KIM
;
Chan Young LEE
;
Duck Hwan KIM
;
Jae Hwan LEE
;
Min Chul LEE
Author Information
1. Department of Surgery, College of Medicine, Dankook University.
- Publication Type:Original Article
- Keywords:
Breast cancer;
Prognostic factors;
E-cadherin
- MeSH:
Adenocarcinoma;
Breast Neoplasms*;
Breast*;
Cadherins*;
Epithelial Cells;
Female;
Glycoproteins;
Humans;
Phenotype;
Recurrence
- From:Journal of the Korean Surgical Society
1998;54(6):810-816
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Breast Cancer in women poses a problem, and it can be difficult at times to evaluate the possibility of the cancer's recurrence in node negative early cancer. Reliable prognostic markers are needed in breast-cancer management to help clinicians identify patient with high risk of recurrence and arrive at more rational decisions for proper treatment. E-cadherin is a glycoprotein that mediates Ca2 -dependent cell-cell adhesion and maintenance of the epithelial cell phenotype. It has been implicated as an invasion-suppressing protein in experimental systems and in human tumors, and alterations in the cadherin function have been implicated in tumor progression in a number of adenocarcinomas. In this study, the expression of E-cadherin was reduced in 35.3% of the case reviewed(12/34), and we could find no clinical relation between the known prognostic factors except tumor stage(p<0.05), and the degree of E-cadherin expression.
