Recent advances in nanocarrier-based drug delivery systems in treatment of rheumatoid arthritis.
10.19540/j.cnki.cjcmm.20230614.601
- Author:
Xiao LIANG
1
;
Ya-Lan LI
1
;
Hao-Tian BAI
1
;
Qing-Yu ZHANG
1
;
Zhan XIAO
1
;
Xin SUN
1
;
Wu-Long WEN
1
;
Wei-Ye ZHANG
1
;
Jing YANG
2
;
Rui WANG
1
Author Information
1. School of Pharmacy, Heilongjiang University of Chinese Medicine Harbin 150040, China.
2. Basic Medical College, Heilongjiang University of Chinese Medicine Harbin 150040, China.
- Publication Type:Journal Article
- Keywords:
active targeting;
drug delivery system;
nanotechnology;
passive targeting;
rheumatoid arthritis
- MeSH:
Humans;
Quality of Life;
Drug Delivery Systems;
Arthritis, Rheumatoid/drug therapy*;
Autoimmune Diseases/drug therapy*;
Nanotechnology
- From:
China Journal of Chinese Materia Medica
2023;48(18):4874-4883
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis(RA) is a widely prevalent autoimmune inflammatory disease that severely affects patients' quality of life. Currently, conventional formulations against RA have several limitations, such as nonspecificity, poor efficacy, large drug dosages, frequent administration, and systemic side effects. Nanotechnology-based drug delivery systems have emerged as a promising stra-tegy for the diagnosis and treatment of RA since nanotechnology can overcome the limitations of traditional treatments and simplify the complexity of the disease. These systems enable targeted delivery of anti-inflammatory drugs to the inflamed areas through active and passive targeting, achieving specificity to the joints, overcoming the need for increased dosage and administration frequency, and reducing associated adverse reactions. This article aimed to review nanocarrier-based drug delivery systems in the field of RA and elucidate how nanosystems can be utilized to deliver therapeutic drugs to inflamed joints for controlling RA progression. By discussing the current issues and challenges faced by nanodrug delivery systems and highlighting the urgent need for solutions, this article offers theoretical support for further research on nanotechnology-based co-delivery systems in the future.
