Chemical constituents and their α-glucosidase inhibitory activities of seeds of Moringa oleifera.
10.19540/j.cnki.cjcmm.20230517.201
- Author:
Liang CHEN
1
;
Yin-Zhi CEN
1
;
Yang-Li TU
1
;
Xiang-Jie DAI
1
;
Yong-Jun LI
2
;
Xiao-Sheng YANG
3
;
Lin-Zhen LI
4
Author Information
1. School of Pharmaceutical Sciences, Guizhou Medical University Guiyang 550025, China Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education),Guizhou Medical University Guiyang 550004, China State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University Guiyang 550004, China.
2. Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education),Guizhou Medical University Guiyang 550004, China.
3. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University Guiyang 550004, China.
4. School of Pharmaceutical Sciences, Guizhou Medical University Guiyang 550025, China Key Laboratory of Basic Pharmacology of Ministry of Education, Zunyi Medical University Zunyi 563000, China Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education),Guizhou Medical University Guiyang 550004, China State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University Guiyang 550004, China.
- Publication Type:Journal Article
- Keywords:
carbohydrates;
chemical constituents;
phenolic glycosides;
seeds of Moringa oleifera;
α-glucosidase inhibitory activity
- MeSH:
Moringa oleifera/chemistry*;
alpha-Glucosidases;
Moringa;
Seeds;
Plant Extracts/pharmacology*
- From:
China Journal of Chinese Materia Medica
2023;48(17):4686-4692
- CountryChina
- Language:Chinese
-
Abstract:
The chemical constituents of the seeds of Moringa oleifera were isolated and purified by using Sephadex LH-20, Toyo-pearl HW-40F, silica gel, ODS, and MCI column chromatography. The structures of compounds were identified by high-resolution mass spectrometry, ~1H-NMR, ~(13)C-NMR, HMQC, HMBC, and ~1H-~1H COSY, as well as physicochemical properties of compounds and literature data. Twelve compounds were isolated from 30% ethanol fraction of the seeds of M. oleifera and identified as ethyl-4-O-α-L-rhamnosyl-α-L-rhamnoside(1), ethyl-3-O-α-L-rhamnosyl-α-L-rhamnoside(2),(4-hydroxybenzyl)ethyl carbamate(3),(4-aminophenyl)acetic acid(4), ethyl-α-L-rhamnoside(5), methyl-α-L-rhamnoside(6), moringapyranosyl(7), 2-[4-(α-L-rhamnosyl)phenyl]methyl acetate(8), niaziridin(9), 5-hydroxymethyl furfural(10), 4-hydroxybenzeneacetamide(11), and 4-hydroxybenzoic acid(12). Among them, compounds 1 and 2 are two new compounds, compound 3 is a new natural product, and compounds 4-5 were yielded from Moringa plant for the first time. All compounds were evaluated for α-glucosidase inhibitory activity in vitro. Compound 10 showed excellent inhibitory activity with IC_(50) of 210 μg·mL~(-1).
