Research progress in tigliane-type macrocyclic diterpenoids.
10.19540/j.cnki.cjcmm.20230427.201
- Author:
Hong-Hu TAN
1
;
Meng XIA
2
;
Ping SU
2
;
Lu-Qi HUANG
1
Author Information
1. State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China School of Pharmacy, Nanjing University of Chinese Medicine Nanjing 210023, China.
2. State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
- Publication Type:Journal Article
- Keywords:
bioactivities;
chemical structure;
drug development;
macrocyclic diterpenoids;
tigliane type
- MeSH:
Phorbols;
Molecular Structure;
Diterpenes/chemistry*;
Antiviral Agents;
Phorbol Esters
- From:
China Journal of Chinese Materia Medica
2023;48(17):4620-4633
- CountryChina
- Language:Chinese
-
Abstract:
Tigliane type macrocyclic diterpenoids with special structures and diverse bioactivities are mainly extracted from plants of Euphorbiaceae and Thymelaeaceae. According to the different functional groups, they can be classified into types of phorbol esters, C-4 deoxyphorbol esters, C-12 deoxyphorbol esters, C-16 or C-17 substituted phorbol esters and others. Most of them present promising antiviral activities and cytotoxic activities and are expected to be developed as candidates for anti-AIDS, anti-tuberculosis, and anti-tumor clinical trials, demonstrating great potential for the application in healthcare. This paper reviews 115 novel tigliane-type diterpenoids discovered since 2013 and summarize their chemical structures and bioactivities, aiming to lay a foundation for further development and utilization of these compounds and provide new ideas for the development of clinical drugs.
