Research progress on oxaliplatin-induced neurotoxicity in traditional Chinese medicine (TCM) and western medical cognition and prevention and treatment by TCM.
10.19540/j.cnki.cjcmm.20230605.601
- Author:
Mei-Mei ZHANG
1
;
Zhi-Cheng GONG
2
;
Yan-Yan CHEN
1
Author Information
1. Cancer Institute, Institute of Integrated Chinese and Western Medicine, Affiliated Hospital of Jiangnan University Wuxi 214062, China Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shaanxi University of Chinese Medicine Xi'an 712046, China.
2. Cancer Institute, Institute of Integrated Chinese and Western Medicine, Affiliated Hospital of Jiangnan University Wuxi 214062, China.
- Publication Type:Journal Article
- Keywords:
TCM and western medical cognition;
chemotherapy;
neurotoxicity;
oxaliplatin;
traditional Chinese medicine
- MeSH:
Humans;
Medicine, Chinese Traditional;
Oxaliplatin/adverse effects*;
Artificial Intelligence;
Quality of Life;
Drugs, Chinese Herbal/therapeutic use*;
Antineoplastic Agents/adverse effects*;
Cognition
- From:
China Journal of Chinese Materia Medica
2023;48(17):4610-4619
- CountryChina
- Language:Chinese
-
Abstract:
Chemotherapy is one of the main options in clinical tumor treatment. Although chemotherapy drugs have a good therapeutic effect, they can also cause a series of adverse reactions, such as neurotoxicity. Chemotherapy-induced neurotoxicity is a dose-limi-ting adverse reaction that significantly affects patients' long-term treatment and quality of life. This article reviewed literature from 2000 to the present on chemotherapy-induced neurotoxicity and found that oxaliplatin was the most frequently used chemotherapy drug. Based on the clinical characteristics of oxaliplatin-induced neurotoxicity, this article summarized the understanding of its pathogenesis from both traditional Chinese medicine(TCM) and western medicine perspectives, discussed the role and mechanism of TCM compounds and monomeric components, and explored the research direction of using cutting-edge biotechnology to reveal the mechanism of oxaliplatin-induced neurotoxicity from a temporal-spatial perspective of intercellular communication and the application prospects of an interdisciplinary model combining TCM pathogenesis, western medicine manifestations, and artificial intelligence in precise intervention decision-making for TCM, aiming to provide research ideas for the prevention and treatment of oxaliplatin-induced neurotoxicity and the development of new drugs.
