A new cinnamic acid ester derivative from Liquidambaris Resina.
- Author:
Shao-Ying XU
1
;
Qin-Wen XIAO
1
;
Su-Min ZHAO
1
;
Yi-Jian GUAN
1
;
Liao-Heng YUAN
1
;
Yao ZHU
1
;
Chao-Jie WANG
1
;
Peng-Cheng YAN
1
;
Jian-Yong DONG
1
Author Information
- Publication Type:Journal Article
- Keywords: Liquidambar formosana; Liquidambaris Resina; chemical constituents; cinnamic acid ester
- MeSH: Humans; Oleanolic Acid; Endothelial Cells; Esters; Cinnamates; Triterpenes/chemistry*; Molecular Structure
- From: China Journal of Chinese Materia Medica 2023;48(15):4130-4136
- CountryChina
- Language:Chinese
- Abstract: Twelve compounds were isolated from Liquidambaris Resina by silica gel column chromatography and thin layer chromatography. Their structures were identified on the basis of spectral data, electron capture detector data, and physicochemical properties as(2'R, 3'R)-2',3'-dihydroxy-hydrocinnamyl-(E)-cinnamate(1),(E)-cinnamyl-(E)-cinnamate(2), cinnamic acid(3), 28-norlup-20(29)-en-3-one-17β-hydroperoxide(4), erythrodiol(5), 13β,28-epoxy-30-hydroxyolean-1-en-3-one(6),(3β)-olean-12-ene-3,23-diol(7), 2α,3α-dihydroxy-olean-12-en-28-oic acid(8), 28-hydroxyolean-12-en-3-one(9), 3-epi-oleanolic acid(10), 3-oxo-oleanolic acid(11), and hederagenin(12). Compound 1 was a new cinnamic acid ester derivative and compounds 2-4,6-8, and 12 were isolated from Liquidambaris Resina for the first time. Compounds 4, 5, 10, and 12 exerted inhibitory effects on the proliferation of human umbilical vein endothelial cells(HUVEC) with the IC_(50) values of(17.43±2.17),(35.32±0.61),(27.50±0.80), and(46.30±0.30) μmol·L~(-1), respectively.
