Three new cucurbitane-type triterpenoid glycosides from Citrullus colocynthis and their anti-inflammatory activity.
10.19540/j.cnki.cjcmm.20230421.202
- Author:
Jun-Ling WU
1
;
Yu-Shuang LIU
2
;
Xi ZHAO
1
;
Tao YUAN
3
Author Information
1. College of Life Sciences, Jiangxi Normal University Nanchang 330022, China.
2. Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences Urumqi 830011, China.
3. College of Life Sciences, Jiangxi Normal University Nanchang 330022, China Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences Urumqi 830011, China.
- Publication Type:Journal Article
- Keywords:
Citrullus colocynthis;
anti-inflammatory activity;
chemical constituents;
cucurbitane-type triterpenoid glycosides
- MeSH:
Citrullus colocynthis/chemistry*;
Triterpenes/chemistry*;
Glycosides/chemistry*;
Plant Extracts/chemistry*;
Anti-Inflammatory Agents/pharmacology*
- From:
China Journal of Chinese Materia Medica
2023;48(15):4124-4129
- CountryChina
- Language:Chinese
-
Abstract:
Three new cucurbitane-type triterpenoid glycosides were separated from the ethyl acetate extract of Citrullus colocynthis by a variety of chromatographic techniques. According to the data of NMR, HR-ESI-MS, and/or comparison with the reported data, the three novel cucurbitane-type triterpenoid glycosides were identified as colocynthenin E(1), colocynthenin G(2), and colocynthenin H(3). The cell inflammation model was established with RAW264.7 macrophages exposed to lipopolysaccharide and then used to determine the anti-inflammatory activities of the three compounds. Compounds 2 and 3 showed mild anti-inflammatory activities with the IC_(50) of 48.21 and 40.11 μmol·L~(-1), respectively, compared with that(IC_(50)=7.57 μmol·L~(-1)) of the positive control dexamethasone.
