Discrete element simulation study of mixing process of Guizhi Fuling Capsules: parameter calibration.
10.19540/j.cnki.cjcmm.20230711.301
- Author:
Huan-Zheng LI
1
;
Xue-Fang TANG
2
;
Yu LIN
1
;
Fang-Fang XU
3
;
Xin ZHANG
3
;
Hui-Qing YE
4
;
Wei XIAO
5
;
Zhen-Zhong WANG
5
;
Bing XU
2
Author Information
1. Nanjing University of Traditional Chinese Medicine Nanjing 210023, China.
2. Department of Chinese Medicine Informatics, Beijing University of Traditional Chinese Medicine Beijing 102488, China Beijing Key Laboratory of Chinese Medicine Production Process Control and Quality Evaluation, Beijing Municipal Science and Technology Commission Beijing 102488, China.
3. Jiangsu Kang Yuan Pharmaceutical Company Limited Lianyungang 222001, China State Key Laboratory of New Technology of Chinese Pharmaceutical Processes Lianyungang 222001, China.
4. Jiangsu Kang Yuan Pharmaceutical Company Limited Lianyungang 222001, China.
5. Jiangsu Kang Yuan Pharmaceutical Company Limited Lianyungang 222001, China State Key Laboratory of New Technology of Chinese Pharmaceutical Processes Lianyungang 222001, China National Joint Engineering Research Center for Intelligent Manufacturing of Proprietary Chinese Medicines Lianyungang 222001, China.
- Publication Type:Journal Article
- Keywords:
angle of repose;
contact model;
critical contact parameter;
discrete element method;
simulation parameter calibration
- MeSH:
Wolfiporia;
Calibration;
Powders;
Medicine, Chinese Traditional;
Capsules
- From:
China Journal of Chinese Materia Medica
2023;48(15):4007-4014
- CountryChina
- Language:Chinese
-
Abstract:
The mixing process is a critical link in the formation of oral solid preparations of traditional Chinese medicine. This paper took the extract powder of Guizhi Fuling Capsules and Paeonol powder as research objects. The angle of repose, loose packing density, and particle size of the two powders were measured to calibrate discrete element simulation parameters for the mixing process. The discrete element method was used to calibrate the simulated solid density of Paeonol powder and extract powder of Guizhi Fuling Capsules based on the Hertz-Mindlin with JKR V2 contact model and particle scaling. The Plackett-Burman experimental design was used to screen out the critical contact parameters that had a significant effect on the simulation of the angle of repose. The regression model between the critical contact parameters and the simulated angle of repose was established by the Box-Behnken experimental design, and the critical contact parameters of each powder were optimized based on the regression model. The best combination of critical contact parameters of the extract powder of Guizhi Fuling Capsules was found to be 0.51 for particle-particle static friction coefficient, 0.31 for particle-particle rolling friction coefficient, and 0.64 for particle-stainless steel static friction coefficient. For Paeonol powder, the best combination of critical contact parameters was 0.4 for particle-particle static friction coefficient and 0.19 for particle-particle rolling friction coefficient. The best combination of contact parameters between Paeonol powder and extract powder of Guizhi Fuling Capsules was 0.27 for collision recovery coefficient, 0.49 for static friction coefficient, and 0.38 for rolling friction coefficient. The verification results show that the relative error between the simulated value and the measured value of the angle of repose of the two single powders is less than 1%, while the relative error between the simulated value and the measured value of the angle of repose of the mixed powder with a mass ratio of 1∶1 is less than 4%. These research results provide reliable physical property simulation data for the mixed simulation experiment of extract powder of Guizhi Fuling Capsules and Paeonol powder.
