Material basis and molecular mechanism of Dachengqi Decoction in treatment of acute pancreatitis based on network pharmacology.
10.19540/j.cnki.cjcmm.20191210.401
- Author:
Jing-Yu YANG
1
;
Rui WANG
2
;
Tao JIN
1
;
Lan LI
1
;
Yi-Qin WANG
3
;
Qing XIA
1
;
Dan DU
2
Author Information
1. Department of Integrated Traditional Chinese Medicine & Western Medicine, West China Hospital of Sichuan University Chengdu 610041, China.
2. West China-Washington Mitochondria and Metabolism Centre, West China School of Medicine/West China Hospital of Sichuan University Chengdu 610041, China.
3. Department of Integrated Traditional Chinese Medicine & Western Medicine, West China Hospital of Sichuan University Chengdu 610041, China West China-Washington Mitochondria and Metabolism Centre, West China School of Medicine/West China Hospital of Sichuan University Chengdu 610041, China.
- Publication Type:Journal Article
- Keywords:
Dachengqi Decoction(DCQD);
acute pancreatitis;
molecular mechanism;
network pharmacology
- MeSH:
Acute Disease;
Animals;
Molecular Docking Simulation;
Pancreatitis/drug therapy*;
Plant Extracts/pharmacology*;
Rats;
Rats, Sprague-Dawley;
Signal Transduction
- From:
China Journal of Chinese Materia Medica
2020;45(6):1423-1432
- CountryChina
- Language:Chinese
-
Abstract:
The network pharmacology was used to investigate the material basis and molecular mechanism of Dachengqi Decoction(DCQD) in the treatment of acute pancreatitis(AP). Potential targets of components from DCQD and relevant pathogenic genes of AP were identified through database retrieval. Then, crucial targets were verified with relevant active chemical components via molecular docking. DAVID database was used to explore the functions and pathways involved in the treatment of AP. A total of 108 components were correlated with 28 targets. Molecular docking showed a strong binding ability of key targets and their corresponding compounds. DAVID enrichment analysis showed 438 biological process, 31 molecular functions, 17 cellular components and 96 KEGG pathways. DCQD may achieve its pharmacological effects through anti-inflammatory and anti-oxidative effects, negative regulation of apoptosis and regulation of pancreatic secretion, involving multiple signals, such as IL-17, TNF and NF-κB signaling pathway. In this study, it is the first time to use the method of network pharmacology to reveal the molecular mechanism of DCQD in the treatment of AP by multiple components and multi-signaling pathways, which provides a basis for further biological experiments of AP.
