Investigation on secondary metabolites of endophytic fungus Talaromyces purpurogenus hosted in Tylophora ovate.
10.19540/j.cnki.cjcmm.20191204.201
- Author:
Jing-Yi ZHAO
1
;
Zhen LIU
1
;
Sen-Feng SUN
1
;
Yun-Bao LIU
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050, China.
- Publication Type:Journal Article
- Keywords:
anti-diabetic;
endophytic fungus;
secondary metabolites
- MeSH:
Endophytes/chemistry*;
Hypoglycemic Agents/chemistry*;
Magnetic Resonance Spectroscopy;
Molecular Structure;
Secondary Metabolism;
Talaromyces/chemistry*;
Tylophora/microbiology*;
Xanthine Oxidase/antagonists & inhibitors*
- From:
China Journal of Chinese Materia Medica
2020;45(6):1368-1373
- CountryChina
- Language:Chinese
-
Abstract:
Eight compounds,(R)-2-[5-(methoxycarbonyl)-4-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]acetic acid(1),(3S,4R)-3,4-dihydro-3,4-epoxy-5-hydroxynaphthalen-1(2H)-one(2),(-)-mitorubrinol(3),(-)-mitorubrin(4),(±)-asperlone A(5), terreusinone(6), verrucisidinol(7) and cerebroside C(8) were isolated from the endophytic fungus Talaromyces purpurogenus by using various column chromatographic techniques. Their structures were identified by NMR, MS, CD and optical rotation. Compounds 1 and 2 were new compounds. Their anti-diabetic activities in vitro were evaluated, and compound 1 showed moderate inhibitory activity toward XOD at 10 μmol·L~(-1) with the inhibition rate of 69.9%.
