Advances in research on pharmacological and neuroprotective effects of traditional Chinese medicine after cerebral ischemia.
10.19540/j.cnki.cjcmm.20191022.403
- Author:
Min WANG
1
;
Jian-Xun LIU
1
;
Ming-Jiang YAO
1
;
Jun-Guo REN
1
Author Information
1. Institute of Basic Medical Sciences, Xiyuan Hospital, China Academy of Chinese Medical Sciences Beijing 100091, China.
- Publication Type:Review
- Keywords:
butylphthalide;
cerebral ischemia;
nerve injury;
stroke;
tetramethylpyrazine;
traditional Chinese medicine ingredients
- MeSH:
Benzofurans/therapeutic use*;
Brain Ischemia/drug therapy*;
Cerebral Infarction/drug therapy*;
Drugs, Chinese Herbal/therapeutic use*;
Humans;
Medicine, Chinese Traditional;
Neuroprotective Agents/therapeutic use*;
Panax notoginseng;
Pyrazines/therapeutic use*;
Saponins/therapeutic use*
- From:
China Journal of Chinese Materia Medica
2020;45(3):513-517
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral ischemia is also known as ischemic stroke. In recent years, research on neuroprotection after ischemia has became a hot spot as stroke can result in symptoms of nerve damages such as hemiplegia, learning and memory disorders. The key factors that cause the death of cells include excitotoxicity, oxidative damage, nitrosative stress and inflammation. However, there is no effective preparation for the treatment of post-ischemic nerve defects at present, so it is urgent to find and develop effective drugs for the treatment of nerve damages after ischemia. Traditional Chinese medicine has advantages and potentials in the treatment of neurological diseases. Many scholars have carried out related researches on the active ingredients of traditional Chinese medicine and achieved some good results. In this context, the researches on the neuroprotective effects of traditional Chinese medicines such as tetramethylpyrazine, butylphthalide and total saponins of Panax notoginseng were reviewed. The author found that the neuroprotective researches of traditional Chinese medicine mostly focused on anti-apoptosis, anti-inflammatory and anti-oxidative stress, but those effects were not sounique to the nervous system. Furthermore, most ingredients of traditional Chinese medicine showed a poor water-soluble property. In view of the research status and existing problems of traditional Chinese medicine in nerve injury, the suggestions for the research and development of the potent neuroprotective agents were proposed in this study from the perspective of pharmacological mechanism research and preparation theory.
