Functional prediction of Tanreqing Injection in brain diseases.
10.19540/j.cnki.cjcmm.20191107.201
- Author:
Zhong-Min LYU
1
;
Yi WANG
2
;
Dan-Qiao WANG
2
;
Tao LI
2
;
Hai-Ming ZHANG
2
;
Ying-Lan NIE
2
;
Fu-Jiang SONG
2
;
Jian SUN
2
Author Information
1. Department of Pharmacology, Basic Medical College, Heilongjiang University of Traditional Chinese Medicine Harbin 150040, China State Key Laboratory Breeding Base of Dao-di Herbs, Experimental Research Center, China Academy of Chinese Medical Sciences Beijing 100700, China.
2. State Key Laboratory Breeding Base of Dao-di Herbs, Experimental Research Center, China Academy of Chinese Medical Sciences Beijing 100700, China.
- Publication Type:Journal Article
- Keywords:
Tanreqing Injection;
bioinformatics;
pharmaceutical ingredients in brain composition
- MeSH:
Animals;
Apoptosis;
Brain Diseases/drug therapy*;
Cerebrospinal Fluid/chemistry*;
Chromatography, Liquid;
Drugs, Chinese Herbal/analysis*;
Injections;
Mass Spectrometry;
Rats;
Signal Transduction
- From:
China Journal of Chinese Materia Medica
2020;45(4):937-945
- CountryChina
- Language:Chinese
-
Abstract:
The study explores the application of Tanreqing Injection into brain components in brain diseases. The components of Tanreqing Injection and its existing components in rat cerebrospinal fluid were qualitatively analyzed by liquid chromatography-mass spectrometry(LC-MS). The possible mechanism of action of Tanreqing Injection into brain on brain diseases was predicted by network pharmacological theory. In this study, 17 brain-entry components of Tanreqing Injection were founded, and 222 core targets were obtained from network pharmacological results. The biological processes include 31 items such as negative regulation of apoptotic process, MAPK cascade, Ras protein signal transduction, and 22 items such as PI3 K-Akt signal transduction, MAPK signal transduction and neurotrophic factor signal transduction. Nine brain diseases including stroke, migraine and meningioma were screened out by predicting the effect of Tanreqing Injection on brain components, which provide ideas and directions for further study of a certain encephalopathy and lay a theoretical foundation for further revealing its molecular mechanism.
