A new antimicrobial isobenzoisofuran compound from Cassia pumila.
- Author:
Ling-Min LIAO
1
;
Qian GAO
2
;
Yin-Ke LI
1
;
Jing LI
2
;
Xin LIU
2
;
Xue-Mei LI
2
;
Guang-Yu YANG
1
;
Yan-Qing YE
3
;
Qiu-Fen HU
3
;
Jian-Gang LI
4
;
Miao DONG
3
Author Information
- Publication Type:Journal Article
- Keywords: Cassia pumila; antibacterial activity; isobenzoisofuran
- MeSH: Anti-Bacterial Agents/pharmacology*; Benzofurans/pharmacology*; Cassia/chemistry*; Levofloxacin; Methicillin-Resistant Staphylococcus aureus/drug effects*; Microbial Sensitivity Tests; Phytochemicals/pharmacology*; Plants, Medicinal/chemistry*
- From: China Journal of Chinese Materia Medica 2020;45(4):896-898
- CountryChina
- Language:Chinese
- Abstract: A new isobenzoisofuran(1) has been isolated from the whole plant of Cassia pumila using various chromatographic techniques, including silica gel, Sephadex, MCI-gel resin, and RP-HPLC, and its structure was determined as 9-(2-hydroxyethyl)-2,2-dimethyl-2H-furo[3,4-g]chromen-6(8H)-one. This compound was also evaluated for its antibacterial activity. The results showed that it had prominent antibacterial activity with MIC_(90) value of(45.2±4.2) μg·mL~(-1) for methicillin resistant Staphylococcus aureus(MRSA) strain. This value was closed to that of levofloxacin [with MIC_(90) value(48.5±4.3) μg·mL~(-1)].
