Physiochemical property variation in traditional Chinese medicine decoction before or after precipitation in alcohol and its relationship with wall stickiness in spray drying.
10.19540/j.cnki.cjcmm.20191217.306
- Author:
Xiao-Hong SHI
1
;
Ri-Zhao YANG
1
;
Li-Jie ZHAO
1
;
Yan-Long HONG
2
;
Yi FENG
1
;
You-Jie WANG
1
Author Information
1. Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine under Ministry of Education,Innovation Research Institute of TCM, Shanghai University of Traditional Chinese Medicine Shanghai 201203, China.
2. Shanghai Innovation Center of Traditional Chinese Medicine Health Service, Shanghai University of Traditional Chinese Medicine Shanghai 201203, China.
- Publication Type:Journal Article
- Keywords:
dynamic surface tension;
hot-melt stickiness;
spray drying;
water extraction and alcohol precipitation
- MeSH:
Cluster Analysis;
Desiccation/methods*;
Drugs, Chinese Herbal/chemistry*;
Ethanol/chemistry*;
Hot Temperature;
Least-Squares Analysis;
Medicine, Chinese Traditional;
Principal Component Analysis
- From:
China Journal of Chinese Materia Medica
2020;45(4):846-853
- CountryChina
- Language:Chinese
-
Abstract:
To explore the relationship between the variations of the physiochemical properties of traditional Chinese medicine(TCM) decoction before or after precipitation in alcohol and the wall stickiness in spray drying. In this study, widely used TCMs in clinic were selected to determine the physiochemical properties of TCM decoction before or after precipitation in alcohol separately.Afterwards, the principle component analysis(PCA),Hierarchical cluster analysis(HCA),and orthogonal partial least squares-discriminate analysis(OPLS-DA) were used to evaluate the relationship between the variations of those liquid before or after precipitation in alcohol and hot-melt stickiness in spray drying.Three types of statistical analysis methods all indicated that ethanol precipitation affected physiochemical properties of TCM decoction, and the variations of physical properties showed significant association with hot-melt stickiness in spray drying.The results of PCA-X and HCA suggested that the dynamic surface tension(DST) was impacted most by the alcohol deposition treatment,at the same time,the other 5 physiochemical properties were also affected.OPLS-DA verified that PCA-X and HCA results, and revealed that DST,equilibrium surface tension(EST) and pH were significantly affected by alcohol deposition treatment,and the order of the affecting factors from high to low was DST,EST and pH.Therefore,the downward trend of DST and pH were the important factors that directly affected the hot-melt stickiness of TCM after precipitation in alcohol,which would be probably caused by losing macromolecules alcoholic insoluble components and increasing relative proportions of organic acid and small molecule sugar.
