Research progress on chemical constituents of Citrullus colocynthis and their pharmacological effects.
10.19540/j.cnki.cjcmm.20191104.201
- Author:
Min-Si ZHENG
1
;
Yu-Shuang LIU
2
;
Tao YUAN
2
;
Li-Ya LIU
1
;
Zhi-Yong LI
1
;
Xiu-Lan HUANG
1
Author Information
1. School of Pharmacy, Minzu University of China Beijing 100081, China.
2. The Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences Urumqi 830011, China.
- Publication Type:Review
- Keywords:
Citrullus colocynthis;
anti-cancer;
anti-diabetes;
cucurbitacin
- MeSH:
China;
Citrullus colocynthis/chemistry*;
Drugs, Chinese Herbal/pharmacology*;
Phytochemicals/pharmacology*
- From:
China Journal of Chinese Materia Medica
2020;45(4):816-824
- CountryChina
- Language:Chinese
-
Abstract:
Citrullus colocynthis is widely distributed in the desert regions of the world. C. colocynthis has shown to improve constipation, liver diseases, jaundice, typhoid fever, diabetes and asthma in traditional use. As a kind of exterritorialy medicinal material, C. colocynthis has been used in China and introduced successfully. The main active ingredients of C. colocynthis are cucurbitacin, flavonoids, alkaloids and phenolic acids, which have been proven to have antioxidant, anti-diabetic, anti-pathogenic microorganisms and anti-cancer activities in modern pharmacological research. This paper reviews the traditional application, chemical composition and pharmacological effects of C. colocynthis, and provides reference for the in-depth study for the efficacy and mechanism of different components of C. colocynthis.
