Efficacy and safety of Shentong Zhuyu Decoction for lumbar disc herniation: systematic review and Meta-analysis.
10.19540/j.cnki.cjcmm.20191011.501
- Author:
Kai SUN
1
;
Li-Guo ZHU
1
;
Xu WEI
2
;
Jie YU
2
;
Min-Shan FENG
1
;
He YIN
2
;
Long LIANG
2
;
Yi-Li ZHANG
3
;
Bao-Yu QI
2
Author Information
1. Wangjing Hospital of China Academy of Chinese Medical Sciences Beijing 100102, China Beijing Key Laboratory of Orthopedics of Traditional Chinese Medicine Beijing 100007, China.
2. Wangjing Hospital of China Academy of Chinese Medical Sciences Beijing 100102, China.
3. Beijing University of Chinese Medicine Beijing 100029, China.
- Publication Type:Systematic Review
- Keywords:
Meta-analysis;
Shentong Zhuyu Decoction;
efficacy;
lumbar disc herniation;
safety;
systematic review
- MeSH:
China;
Drugs, Chinese Herbal/therapeutic use*;
Humans;
Intervertebral Disc Displacement/drug therapy*;
Randomized Controlled Trials as Topic
- From:
China Journal of Chinese Materia Medica
2020;45(5):1159-1166
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the clinical efficacy and safety of Shentong Zhuyu Decoction in the treatment of lumbar disc herniation, in order to provide evidence for its clinical application. PubMed, Cochrane Library, EMbase, CNKI, WanFang, VIP, CBM and Clinical Trials.gov databases were sysmatically retrieved. Two researchers independently searched, screened and extracted data. Randomized controlled trials in line with the inclusion criteria were included in the study. The article quality was assessed with the bias risk tool in the Cochrane Handbook. Meta-analysis was performed using RevMan 5.3. A total of 604 articles were obtained from the retrieval, and 824 patients in 9 studies were finally selected through screening. The course of treatment was about 1 month, and all of the studies were completed in China. Meta-analysis showed that the efficacy of Shentong Zhuyu Decoction in the treatment of lumbar disc herniation was better than that of the control group(RR=1.19, 95%CI[1.12, 1.26], P<0.000 01), including the comparison with Yaotongning Capsules(RR=1.10, 95%CI[1.02, 1.19], P=0.01) and diclofenac sodium tablets(RR=1.26, 95%CI[1.11, 1.44], P=0.000 4). In VAS pain score, Shentong Zhuyu Decoction had also obvious advantages(MD=-3.70, 95%CI[-6.31,-1.09], P=0.005). In addition, the number of adverse events in the Shentong Zhuyu Decoction group was lower than that in the control group. Shentong Zhuyu Decoction can effectively alleviate discomfort symptoms of patients with LDH. It has an obvious clinical efficacy and less adverse reactions. However, restricted by the quality of the included literatures, prospective, multi-center, large-sample-size randomized controlled trials are still needed to further improve the clinical evidence of the effect of Shentong Zhuyu Decoction in the treatment of LDH.
