Network pharmacology study on potential active components in volatile oil of Dictamni Cortex.
10.19540/j.cnki.cjcmm.20191205.201
- Author:
Huang-Jin TONG
1
;
Yun SHI
2
;
Jing JI
3
;
Xun GAO
3
;
Dong-Yi YANG
3
;
Sha-Li DU
2
;
Wei-Dong LI
2
;
Kun-Ming QIN
4
Author Information
1. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing 210028, China Jiangsu Province Academy of Traditional Chinese Medicine Nanjing 210028, China School of Pharmacy, Nanjing University of Chinese Medicine Nanjing 210023, China.
2. School of Pharmacy, Nanjing University of Chinese Medicine Nanjing 210023, China.
3. School of Pharmacy, Jiangsu Ocean University Lianyungang 222005, China.
4. School of Pharmacy, Jiangsu Ocean University Lianyungang 222005, China Nanjing Haiyuan Prepared Slices of Chinese Crude Drugs Co., Ltd. Nanjing 210061, China.
- Publication Type:Journal Article
- Keywords:
Dictamni Cortex;
network pharmacology;
target of action;
volatile oil
- MeSH:
Dictamnus/chemistry*;
Drugs, Chinese Herbal/pharmacology*;
Oils, Volatile/pharmacology*;
Protein Interaction Maps;
Quality Control;
Software
- From:
China Journal of Chinese Materia Medica
2020;45(5):1135-1141
- CountryChina
- Language:Chinese
-
Abstract:
There are many chemical components in the volatile oil of Dictamni Cortex. The complex network relationship of "component-target-disease" can be revealed by using the network pharmacology method, and the mechanism of the efficacy of Dictamni Cortex can be revealed. In this study, we used Swiss Target Prediction database to predict the target of action, STRING database to build protein interaction network, and Cytoscape software to build "component-target-disease" network. The results showed that the antibacterial, anti-inflammatory and antiallergic effects of Dictamni Cortex were closely related to the components of thymol methyl ether, elemenol, anethole, and the related targets of each component were cross-linked to play a multi-target pharmacodynamic role. This study laid a foundation for the study of the effective substance basis and quality control evaluation of the Dictamni Cortex, and provided a scientific basis for further revealing its mechanism.
