Effect of Lepidium meyenii (Maca) on neurotransmitter level and neuro-endocrine-immune network of deficiency-cold and deficiency-heat syndrome rats.
10.19540/j.cnki.cjcmm.20190916.401
- Author:
Na YUE
1
;
Xue ZHOU
1
;
Wen-Ting FEI
1
;
Ai-Min LI
2
;
Zi-Chen WANG
1
;
Chun WANG
1
;
Jian-Jun ZHANG
1
Author Information
1. School of Basic Medical Science, Beijing University of Chinese Medicine Beijing 100029, China.
2. New Era Health Industry(Group) Co., Ltd. Beijing 102206, China.
- Publication Type:Journal Article
- Keywords:
Lepidium meyenii(Maca);
cyclic nucleotides;
deficiency-cold syndrome;
deficiency-heat syndrome;
hypothalamic-pituitary-adrenal axis;
immunity;
neurotransmitter
- MeSH:
Animals;
Drugs, Chinese Herbal/pharmacology*;
Endocrine System/drug effects*;
Hypothalamo-Hypophyseal System;
Immune System/drug effects*;
Lepidium/chemistry*;
Medicine, Chinese Traditional;
Nervous System/drug effects*;
Neurotransmitter Agents;
Nucleotides, Cyclic;
Pituitary-Adrenal System;
Plant Extracts/pharmacology*;
Rats;
Rats, Sprague-Dawley;
Temperature
- From:
China Journal of Chinese Materia Medica
2020;45(5):1004-1010
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this paper was to study the effect of Lepidium meyenii(Maca) on cyclic nucleotides, neurotransmitter levels and hypothalamic-pituitary-adrenal axis and immunization of deficiency-cold and deficiency-heat syndrome rats, in order to explore the cold and hot medicinal properties of Maca. SD rats were divided into blank group, deficiency-cold syndrome group, Cinnamomi Cortex of deficiency-cold syndrome(30 g·kg~(-1)) group, high and low-dose Maca groups(2.4, 1.2 g·kg~(-1)), deficiency-heat syndrome group, Phellodendri Chinensis Cortex(PCC) of deficiency-heat syndrome(5 g·kg~(-1)), and high and low-dose Maca groups(2.4, 1.2 g·kg~(-1)). The rats were treated with intramuscular injection of hydrocortisone(20 mg·kg~(-1)) or dexamethasone sodium phosphate(0.35 mg·kg~(-1)) for 21 days to set up the deficiency-cold and deficiency-heat model. The levels of cAMP, cGMP, NE, DA, 5-HT, CRH, ACTH, CORT and IgM, IgG, C3, C4 were detected by radio immunoassay. Both the high-dose Maca group and the low-dose Maca group can significantly improve the overall state and body weight of rats with deficiency-cold syndrome(P<0.01, P<0.05), significantly increasing cAMP, cAMP/cGMP, NE, DA, ACTH(P<0.01, P<0.001), and significantly decreasing 5-HT(P<0.01, P<0.001). However, high-dose and low-dose Maca groups could not improve the deficiency-heat syndrome, and the levels of cAMP, cGMP, cAMP/cGMP, NE, DA, 5-HT and ACTH were not statistically significant. Maca had a significant regulatory effect on CORT, IgM, IgG and C3 content of rats with deficiency-cold and deficiency-heat syndrome(P<0.01, P<0.05, P<0.001). Maca showed the same effect with Cinnamomi Cortex in adjusting the levels of deficiency-cold rats, but in opposition to Phellodendri Chinese Cortex. This paper confirmed that Maca was slightly warm based on its effect on cyclic nucleotide levels and neuro-endocrine-immune networks by the pharmacological experimental method.
