Intestinal absorption properties of Gastrodiae Rhizoma powder with different particle size by circulation pass perfusion model in rats.
10.19540/j.cnki.cjcmm.20191018.201
- Author:
Mei LI
1
;
Fan LIU
1
;
Yan CHEN
1
;
Ting-Ting CHEN
1
;
Yue-Ting LI
1
;
Si-Ying CHEN
1
;
Yong HUANG
1
;
Lin ZHENG
1
;
Yong-Jun LI
1
;
Ai-Min WANG
1
;
Zi-Peng GONG
1
Author Information
1. Provincial Key Laboratory of Pharmaceutics in Guizhou, State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Research Center for the Development and Application of Ethnic Medicine and Traditional Chinese Medicine, School of Pharmacy, Guizhou Medical University Guiyang 550004, China.
- Publication Type:Journal Article
- Keywords:
Gastrodiae Rhizoma;
in vivo circulation pass perfusion model;
intestinal absorption;
ultrafine powder
- MeSH:
Animals;
Chromatography, High Pressure Liquid;
Drugs, Chinese Herbal/pharmacokinetics*;
Gastrodia;
Intestinal Absorption;
Particle Size;
Powders;
Rats;
Tandem Mass Spectrometry
- From:
China Journal of Chinese Materia Medica
2020;45(1):179-187
- CountryChina
- Language:Chinese
-
Abstract:
This study is to study the absorption properties of different particle size of Gastrodiae Rhizoma powder in rats. In vivo circulation pass perfusion model combined with ultra high performance liquid chromatography-mass spectrometry(UPLC-MS/MS) method was used to determine the cumulative absorption of each component in different particle size of Gastrodiae Rhizoma powder, and the effect of different particle size, different concentrations, different intestine segments and bile on the intestine absorption of gastrodin and other compositions in Gastrodiae Rhizoma powder was investigated to illuminate the absorption properties and compare the absorption difference of gastrodin and other compositions in Gastrodiae Rhizoma powder in different particle size. The results showed that the absorption of gastrodin in each intestinal segment has no significant difference, pointing out that gastrodin may be passive absorption and the absorption of barrison glycosides may be active absorption; the absorption of gastrodin in ultrafine powder was better than that of common powder and superfine powder of Gastrodiae Rhizoma; the absorption of these barrison glycosides was good in ultrafine powder of Gastrodiae Rhizoma under the high concentration. However, an appropriate degree of superfine grinding can promote the absorption of active ingredients of Gastrodiae Rhizoma. This test can provide information for the deep development of Gastrodiae Rhizoma.
