Permeation mechanism of phenolic acid components from traditional Chinese medicine on PES membrane separation process.
10.19540/j.cnki.cjcmm.20191001.306
- Author:
Sha-Sha HUANG
1
;
Wen-Jing ZHAO
1
;
Yue ZHANG
1
;
Bo LI
1
;
Lin-Mei PAN
1
;
Wei-Wei YAO
1
;
Hong-Bo LIU
2
;
Ye-Fan LI
2
;
Zhi-Shu TANG
2
;
Hua-Xu ZHU
1
Author Information
1. National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Jiangsu Collaboration Innovation Center of Chinese Medical Resources Industrialization, Jiangsu Plant Medicine Research and Development Center, Nanjing University of Chinese Medicine Nanjing 210023, China.
2. Collaborative Innovation Center of Chinese Medicinal Resources Industrialization of Shanxi Province, Shaanxi University of Chinese Medicine Xianyang 712046, China.
- Publication Type:Journal Article
- Keywords:
Chinese medicine chemical composition;
PES membrane;
membrane permeation mechanism;
phenolic acid components
- MeSH:
Drugs, Chinese Herbal/analysis*;
Hydroxybenzoates/isolation & purification*;
Medicine, Chinese Traditional;
Membranes, Artificial;
Molecular Structure;
Molecular Weight
- From:
China Journal of Chinese Materia Medica
2020;45(1):106-112
- CountryChina
- Language:Chinese
-
Abstract:
To explore the permeation mechanism of micro-molecule medicinal ingredients of water extract of tradition Chinese medicine(TCM) in membrane separation process. With phenolic acid components as the model solute, five phenolic acids with similar molecular weight and structure, namely gallic acid, protocatechuate acid, 4-hydroxybenzoic acid, 3-hydroxybenzoic acid and salicylic acid, were selected in the PES membrane separation experiments. With the relative flux and the transmission rate as indexes, the scanning electron microscopy(SEM) and the electrochemical impedance spectroscopy(EIS) were used to analyze the permeation mechanism of different phenolic acid components. The results showed phenolic acids with similar molecular weight had different permeation behaviors, with decreased relative flux and increased solute permeation with the increase of solute concentration. According to the permeation behavior analyzed by the molecular structure of solute, the transmission rate of phenolic acids increased with the increase of the number of hydroxyl, and the order of substituent positions of phenolic acids based on the permeation rate as follows: para-substituted > meta-substitution > ortho-substitution. Electrochemical impedance spectroscopy reflected the role of charge repulsion in the membrane process; that is to say, the greater the resistance is, the less the solute permeation is. Therefore, the permeation phenomenon of the phenolic acid components in the PES membrane is not only the result of simple sieving mechanisms, but also has the effects of steric hindrance and charge repulsion during the membrane process.
