Quantification of hepatotoxic pyrrolizidine alkaloid adonifoline in traditional Chinese medicine preparations containing Senecionis Scandentis Herba.
10.19540/j.cnki.cjcmm.20191001.301
- Author:
Fen XIONG
1
;
Kai-Yuan JIANG
1
;
Ai-Zhen XIONG
1
;
Zheng-Cai JU
1
;
Li YANG
2
;
Zheng-Tao WANG
2
Author Information
1. Key Laboratory for Standardization of Chinese Medicines under MOE, Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine Shanghai 201203, China.
2. Key Laboratory for Standardization of Chinese Medicines under MOE, Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine Shanghai 201203, China Shanghai R&D Center for Standardization of Traditional Chinese Medicines Shanghai 201203, China.
- Publication Type:Journal Article
- Keywords:
Senecionis Scandentis Herba;
UPLC-MS;
adonifoline;
pyrrolizidine alkaloids;
traditional Chinese medicine preparation
- MeSH:
Chromatography, Liquid;
Drugs, Chinese Herbal/standards*;
Lactones/analysis*;
Medicine, Chinese Traditional;
Pyrrolizidine Alkaloids/analysis*;
Senecio/chemistry*;
Tandem Mass Spectrometry
- From:
China Journal of Chinese Materia Medica
2020;45(1):92-97
- CountryChina
- Language:Chinese
-
Abstract:
Pyrrolizidine alkaloids(PAs) are a kind of natural toxins, which can cause severe hepatotoxicity, pulmonary toxicity, genotoxicity, neurotoxicity, embryotoxicity and even death. Therefore, international organizations and countries such as World Health Organization have paid great attention to herbal medicines and preparations containing PAs. PAs are widely distributed in Chinese herb medicines and contained in hundreds of traditional Chinese medicine preparations. The content of adonifoline, the main PAs in Senecionis Scandentis Herba, shall be less than 0.004% in herbal medicines as described in Chinese pharmacopeia. However, there is no guidance in preparations which contain Senecionis Scandentis Herba. In this study, 14 preparations were analyzed by an UPLC-MS method. Among them, 8 preparations were found to contain adonifoline much higher than the content limits of such countries as Germany, Netherlands and New Zealand. And the highest contents of adonifoline were found in Qianbai Biyan Tablets and Qianbai Biyan Capsules, which are officially recorded in Chinese Pharmacopeia. The contents of adonifoline varied in different batches of the same preparations. The highest content was 156.10 μg·g~(-1) Qianbai Biyan Tablets, whose daily intake of adonifoline was up to 1 030.26 μg according to the recommended dosage of the preparation. Our results showed the potential risk of these preparations, and the content limit of adonifoline shall be inspected Chinese medicine preparations containing Senecionis Scandentis Herba.
