Molecular regulative mechanisms of NLRP3 inflammasome activation in diabetic nephropathy and interventional effects of Chinese herbal medicine.
10.19540/j.cnki.cjcmm.20190618.402
- Author:
Wen-Wen WANG
1
;
Wen-Bei HAN
2
;
Yi-Gang WAN
3
;
Yue TU
4
;
Bu-Hui LIU
5
;
Ying-Lu LIU
2
;
Wei WU
3
;
Hong-Yun YEE
2
;
Qi-Jun FANG
3
;
Jian YAO
6
Author Information
1. Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing 210008, China Department of Nephrology,Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine Wenzhou 325000, China.
2. Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing 210008, China.
3. Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School Nanjing 210008, China.
4. Department of Traditional Chinese Medicine Health Preservation, Acupuncture and Moxibustion and Massage College·Health Preservation and Rehabilitation College, Nanjing University of Chinese Medicine Nanjing 210023, China.
5. Department of Nephrology, the Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing 210029, China.
6. Division of Molecular Signaling, Department of Advanced Biomedical Research, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi Yamanashi 409-3898, Japan.
- Publication Type:Journal Article
- Keywords:
Chinese herbal medicines;
NLRP3 inflammasome;
diabetic nephropathy;
molecular mechanism;
signaling pathway
- MeSH:
Caspase 1/immunology*;
Diabetes Mellitus/drug therapy*;
Diabetic Nephropathies/immunology*;
Drugs, Chinese Herbal/therapeutic use*;
Humans;
Inflammasomes/immunology*;
Interleukin-18/immunology*;
Interleukin-1beta/immunology*;
NIMA-Related Kinases;
NLR Family, Pyrin Domain-Containing 3 Protein/immunology*
- From:
China Journal of Chinese Materia Medica
2020;45(1):7-13
- CountryChina
- Language:Chinese
-
Abstract:
The progression of renal damage in diabetic nephropathy(DN)is closely related to Nod-like receptor protein3(NLRP3)inflammasome activation. The characteristics of NLRP3 inflammasome activation include the changed expression and combination levels of NLRP3, apoptosis-associated speck-like protein(ASC)and pro-caspase-1, the increased expression levels of caspase-1, interleukin(IL)-1β and IL-18 and the excessive release levels of the relative inflammatory mediators. Its molecular regulative mechanisms involve the activation of multiple signaling pathways including reactive oxygen species(ROS)/thioredoxin-interacting protein(TXNIP)pathway, nuclear factor(NF)-κB pathway, nuclear factor erythroid-related factor 2(Nrf2)pathway, long non-coding RNA(lncRNA)pathway and mitogen-activated protein kinases(MAPKs)pathway. In addition, more importantly, never in mitosis aspergillus-related kinase 7(Nek7), as a kinase regulator, could target-combine with NLRP3 at upstream to activate NLRP3 inflammasome. Some extracts of Chinese herbal medicines(CHMs)such as quercetin, curcumin, cepharanthine, piperine and salidroside, as well as Chinese herbal compound prescriptions such as Wumei Pills both could treat NLRP3 inflammasome to ameliorate inflammatory renal damage in DN. Therefore, accurately clarifying the targets of anti-inflammatory CHMs and Chinese herbal compound prescriptions delaying DN progression by targeting the molecular regulative mechanisms of NLRP3 inflammasome activation will be one of the development directions in the future.
