Current research analysis and prospects on sensitization effect of artesunate on anti-cancer radiotherapy and chemotherapy.
10.19540/j.cnki.cjcmm.20190828.405
- Author:
Wen-Jia CHEN
1
;
Xia MAO
1
;
Yan-Qiong ZHANG
1
;
Na LIN
1
Author Information
1. Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China.
- Publication Type:Review
- Keywords:
anti-cancer;
artesunate;
chemotherapy;
radiotherapy;
sensitization
- MeSH:
Artesunate/therapeutic use*;
Carboplatin/therapeutic use*;
Cell Line, Tumor;
Cell Proliferation;
Cisplatin/therapeutic use*;
Doxorubicin/therapeutic use*;
Humans;
Neoplasms/radiotherapy*;
Radiation-Sensitizing Agents/therapeutic use*
- From:
China Journal of Chinese Materia Medica
2019;44(23):5231-5239
- CountryChina
- Language:Chinese
-
Abstract:
The wide application of artemisinins in the treatment of multiple cancers reflects the advantages of traditional Chinese medicine used in this field. The existing basic and clinical studies have revealed that artesunate can effectively suppress the malignant progression of breast cancer,colon cancer,leukemia,melanoma,ovarian cancer,prostate cancer,kidney cancer and various tumors in central nervous system. The pharmacological mechanisms of artesunate against cancers are reflected in many aspects,such as inhibiting tumor cell proliferation,invasion and metastasis,inducing tumor cell apoptosis and autophagy,regulating cell signal transduction and inhibiting tumor angiogenesis. Meanwhile,growing experimental evidences have indicated that artesunate has been used for the sensitization of radiotherapy with X-ray,β-ray,γ-ray and~(60)Co γ-ray,as well as chemotherapy with cisplatin,carboplatin and doxorubicin.This review collected basic and clinical studies on the sensitization effect of artesunate on anti-cancer radiotherapy and chemotherapy published on PubMed and CNKI during April 2000 and February 2019,and summarized the clinical positioning and application of artesunate,with the aim to provide a more comprehensive explanation on the sensitization effect of artesunate on anti-cancer radiotherapy and chemotherapy,and offer the inspiration and ideas for the development of radiotherapy and chemotherapy sensitizers,as well as cancer resistance reversal agents.
