Analysis and health risk assessment of aflatoxin B_1 residue in Ziziphi Spinosae Semen.
10.19540/j.cnki.cjcmm.20190624.202
- Author:
Mei-Feng SUN
1
;
Xiao-Wen DOU
2
;
Lei ZHANG
2
;
Jian-Hua WANG
3
;
Ming ZHAO
4
;
Zhen OUYANG
4
;
Mei-Hua YANG
2
Author Information
1. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Ministry of Education,Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences,Peking Union Medical College Beijing 100193,China School of Pharmacy,Jiangsu University Zhenjiang 212013,China.
2. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Ministry of Education,Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences,Peking Union Medical College Beijing 100193,China.
3. College of Agronomy,Shandong Agricultural University Taian 271018,China.
4. School of Pharmacy,Jiangsu University Zhenjiang 212013,China.
- Publication Type:Journal Article
- Keywords:
MOE;
Monte Carlo;
Ziziphi Spinosae Semen;
aflatoxins;
risk assessment
- MeSH:
Aflatoxin B1/analysis*;
Chromatography, High Pressure Liquid;
Drug Contamination;
Plant Preparations/analysis*;
Risk Assessment;
Ziziphus/chemistry*
- From:
China Journal of Chinese Materia Medica
2019;44(23):5078-5082
- CountryChina
- Language:Chinese
-
Abstract:
This study aimed to analyze the residues of aflatoxin B_1( AFB_1) in Ziziphi Spinosae Semen from different producing areas and to assess the health risk of aflatoxin B_1 residue based on the obtained data. A total of 72 samples of Ziziphi Spinosae Semen from different areas were detected by IAC-HPLC-FLD. Based on the data of AFB_1 pollution,a probabilistic assessment model with Monte Carlo simulation was developed. Then,the risk assessment of AFB_1 exposure by Ziziphi Spinosae Semen intake was carried out by MOE( margin of exposure). The results showed that 32 out of 72 of samples( 44. 4%) were found to be contaminated with AFB_1,and the average and maximum concentration of AFB_1 in samples was 5. 42 μg·kg~(-1) and 55. 09 μg·kg~(-1),respectively. After health risk assessment,the average and 97. 5%( 90% confidence interval) exposure level of daily exposure of AFB_1 by Ziziphi Spinosae Semen intake were 0. 008 6( 0. 008 1-0. 009 2) and 0. 057 3( 0. 053 2-0. 061 4) μg·kg~(-1)·d~(-1),respectively. The results showed common use of Ziziphi Spinosae Semen had low level of risk associated with AFB_1. However,the high consumption of Ziziphi Spinosae Semen showed a higher risk than common intake,requiring attention. This study laid a foundation for clinical safe prescription of Ziziphi Spinosae Semen.
