Analysis of arsenic speciation in Sepiae Endoconcha and research on its limit standard.
10.19540/j.cnki.cjcmm.20190903.201
- Author:
Xiao-Dong ZHU
1
;
Jiao-Yang LUO
2
;
Dan-Dan KONG
2
;
Jian-Jie WU
3
;
Ping SHENG
4
;
Mei-Hua YANG
2
Author Information
1. College of Traditional Chinese Medicine,Xinjiang Medicine University Urumqi 830011,China Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100193,China Traditional Chinese Medicine Hospital of Urumqi Urumqi 830000,China.
2. Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100193,China.
3. College of Traditional Chinese Medicine,Xinjiang Medicine University Urumqi 830011,China Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100193,China.
4. College of Traditional Chinese Medicine,Xinjiang Medicine University Urumqi 830011,China.
- Publication Type:Journal Article
- Keywords:
Sepiae Endoconcha;
arsenic speciation;
inorganic arsenic;
limit standard
- MeSH:
Animals;
Arsenic/analysis*;
Arsenicals/analysis*;
Chromatography, High Pressure Liquid;
Drug Contamination;
Environmental Pollution;
Mass Spectrometry;
Medicine, Chinese Traditional;
Sepia/chemistry*
- From:
China Journal of Chinese Materia Medica
2019;44(23):5065-5071
- CountryChina
- Language:Chinese
-
Abstract:
Sepiae Endoconcha is a common marine animal medicine,which generally contains high concentration of arsenic( As).The Chinese Pharmacopoeia( 2010 edition,part I) stipulated that the total As content of Sepiae Endoconcha should not exceed 2 mg·kg~(-1),while this limit was revised to 10 mg·kg~(-1) in the 2015 edition. So far,there is no research on the speciation of As in Sepiae Endoconcha,which made it hard to accurately evaluate its security risk. In this study,32 batches of Sepiae Endoconcha from different sources were collected. The safety risk assessment was carried out by determining the total As content and As speciation,inorganic As[As( Ⅲ),As( Ⅴ) ]and organic As( MMA,DMA,As C,As B) by HPLC-ICP-MS,and then the limit standard was discussed. The results showed that As B was the main form of As in Sepiae Endoconcha,followed by DMA and As( Ⅴ) ． Of the 32 batches of Sepiae Endoconcha,9 batches( accounting for 28%) were detected possessing i As. The maximum concentration of As( Ⅲ) was 103. 3 μg·kg~(-1),and the maximum concentration of As( Ⅴ) was 222. 4 μg·kg~(-1). According to the limit of i As in food,18. 75% of the samples exceeded the standard. The results indicate that there is no simple positive correlation between total As and As morphology in Sepiae Endoconcha. Besides,there is a risk in the total As limit,especially after the relaxation of the total As limit. The problem of high i As content caused by pollution and other factors is difficult to regulate. Since the toxicity of inorganic As is much higher than that of organic As,it is of great practical significance to establish inorganic As form limits in Sepiae Endoconcha.
