Study on quality status of mineral medicine Calamina.
10.19540/j.cnki.cjcmm.20191031.201
- Author:
Guang-Feng SONG
1
;
Zhi-Jie ZHANG
1
;
Rao-Rao LI
1
;
Chen SONG
1
;
Rui-Chao LIN
2
Author Information
1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
2. Beijing Key Laboratory of Traditional Chinese Medicine Quality Evaluation, School of Chinese Materia Medica,Beijing University of Chinese Medicine Beijing 102488, China.
- Publication Type:Journal Article
- Keywords:
Calamina;
calcined Calamina;
countermeasures;
harmful elements;
mineral source;
quality of mineral drugs;
resource starvation
- MeSH:
Arsenic;
Cadmium;
Copper;
Drug Combinations;
Drugs, Chinese Herbal/standards*;
Ferric Compounds/standards*;
Iron;
Lead;
Medicine, Chinese Traditional;
Mercury;
Minerals;
Quality Control;
Trace Elements/analysis*;
Zinc Oxide/standards*
- From:
China Journal of Chinese Materia Medica
2020;45(2):352-360
- CountryChina
- Language:Chinese
-
Abstract:
In this paper, some quality problems of mineral medicine Calamina and calcined Calamina have been discussed after determination and analysis of the quality parameters of a large number of market samples, and the countermeasures are put forward. According to the XRD results, as well as the results of tests included in Chinese Pharmacopoeia(2015 edition), the authenticity of Calamina and calcined Calamina samples were identified. The content of zinc oxide in samples were determined by the method of determination in Chinese Pharmacopoeia. Individually, inductively coupled plasma mass spectrometry(ICP-MS), inductively coupled plasma atomic emission spectrometry(ICP-AES) and atomic fluorescence spectrometry(AFS) methods were used for the determination of impurity elements and harmful elements in Calamina and calcined Calamina samples. Four kinds of impurity elements of magnesium(Mg), iron(Fe), aluminum(Al), calcium(Ca) and five harmful elements such as lead(Pb), cadmium(Cd), arsenic(As), copper(Cu), mercury(Hg) were measured. The study showed that: ① Fake Calamina products on the market were overflowing; ② The mineral origin of the mainstream Calamina in the market is inconsistent with that stipulated in Chinese Pharmacopoeia(2015 edition); ③ The contents of harmful elements Pb and Cd in Calamina and calcined Calamina are generally higher, while the contents of harmful elements As and Cu in some inferior Calaminae are higher; ④ Parts of calcined Calamina were improperly or inadequately processed. In view of these quality problems, the countermeasures are put forward as follows: ① It is suggested that hydrozincite should be approved as the mineral source of Calamina, and be included by Chinese Pharmacopoeia; ② Strengthen the research on the specificity of Calamina identification methods to improve the quality control level; ③ Strengthen the research on the processing of Calamina, and formulate the limit standards for the content of Pb and Cd in Calamina; ④ Carry out research on the artificial synthesis of Calamina and calcined Calamina, in order to cope with the current shortage of Calamina resources and ensure the sustainable development of Calamina medicinal materials.
