Research progress on mechanism of gastrodin and p-hydroxybenzyl alcohol on central nervous system.
10.19540/j.cnki.cjcmm.20190730.401
- Author:
Zhi-Long ZHANG
1
;
Yu-Gang GAO
1
;
Pu ZANG
1
;
Pei-Pei GU
1
;
Yan ZHAO
1
;
Zhong-Mei HE
1
;
Hong-Yan ZHU
1
Author Information
1. College of Chinese Medicinal Materials, Jilin Agricultural University Changchun 130118, China.
- Publication Type:Review
- Keywords:
Gastrodia elata;
central nervous system;
gastrodin;
mechanism of action;
p-hydroxybenzyl alcohol;
pharmacological action
- MeSH:
Benzyl Alcohols/pharmacology*;
Central Nervous System/drug effects*;
Gastrodia/chemistry*;
Glucosides/pharmacology*;
Humans;
Plant Extracts/pharmacology*
- From:
China Journal of Chinese Materia Medica
2020;45(2):312-320
- CountryChina
- Language:Chinese
-
Abstract:
Gastrodin(GAS) and p-hydroxybenzyl alcohol(HBA) are extracts of dried tubers of Gastrodia elata, which is the material basis for its efficacy and belongs to phenolic compounds. Modern pharmacology studies have shown that they have significant effects on central nervous system diseases, such as insomnia, convulsions, depression, ischemic stroke, anxiety, and cognitive impairment, and these diseases are closely related to neurotransmitters and cytokines. This paper described various mechanisms of GAS and HBA monomer components on the central nervous system. They alleviate hippocampal neuronal toxicity mainly by regulating a variety of neurotransmitters, such as acetylcholine, glutamic acid(GLU), γ-aminobutyric acid(GABA), serotonin(5-HT), dopamine(DA), norepinephrine(NE), 5-indoleacetic acid(5-HIAA), high vanillic acid(HVA) and dihydroxyphenylacetic acid(DOPAC), pro-inflammatory cell growth factors, such as IL-1β, IL-6 and TNF-α and relevant receptor functions, and exert neuropharmacological effects by effectively increasing mRNA expressions of brain neurotrophic factors, such as BDNF and GDNF, and further inhibiting the apoptosis of damaged neurons. This paper summarized various mechanisms on the central nervous system, which provides a scientific basis for the further research of the neuropharmacological mechanism of GAS and HBA and the development of new drugs and functional food.
