Study on mechanism and method of membrane preparation and membrane process optimization based on molecular structure analysis of noneffective common macromolecules.
10.19540/j.cnki.cjcmm.20190630.308
- Author:
Hong-Chen SONG
1
;
Jian-Ming WANG
1
;
Li-Wei GUO
2
Author Information
1. Guangdong Key Laboratory of Membrane Materials and Membrane Separation,Guangzhou Institute of Advanced Technology,Chinese Academy of Sciences Guangzhou 511458,China.
2. Guangdong Key Laboratory of Membrane Materials and Membrane Separation,Guangzhou Institute of Advanced Technology,Chinese Academy of Sciences Guangzhou 511458,China Key Laboratory of Separation Engineering of Traditional Chinese Medicine Compounds,Nanjing University of Chinese Medicine Nanjing 210029,China.
- Publication Type:Journal Article
- Keywords:
membrane fouling;
membrane preparation;
membrane process;
noneffective common macromolecules
- MeSH:
Chemistry, Pharmaceutical/methods*;
Medicine, Chinese Traditional;
Membranes, Artificial;
Molecular Structure;
Research Design
- From:
China Journal of Chinese Materia Medica
2019;44(18):4060-4066
- CountryChina
- Language:Chinese
-
Abstract:
The molecular weight of the effective components of traditional Chinese medicine( TCM) is usually less than 1 000.However, " noneffective common macromolecules"( starch,pectin and other macromolecules commonly present in the water extract of TCM) generally have no physiological activity,which restricts the overall advantages of membrane technology to obtain small molecular pharmacodynamic substances,and such macromolecules are the main influence factor of membrane fouling. Therefore,in order to obtain the total pharmacological efficacy of TCM,based on the molecular structure analysis of noneffective common macromolecules,aimed at the key scientific problems in correlation between the molecular structure of noneffective common macromolecules and the pore structure of membrane material,and by referring to the material science theory and molecular simulation method,the correlations between noneffective common macromolecules' molecular structure-solution environment-membrane antagonism were investigated. Multidisciplinary approaches could be integrated to: ① optimize the spatial form of membrane surface and improve the membrane's antifouling ability; ② accurately control the pore structure and the size distribution of membranes,aimed at the innovative preparation technology of special membrane used for TCM; ③ adjust solution environment based on the analysis of molecular structure,and establish the pretreatment method based on the optimization of solution environment. Furthermore,the technical bottleneck on how to obtain the pharmacodynamic micromolecules effectively might be solved,and the theory and technology about TCM pharmaceutical engineering could be developed based on the concept of multivariate and integration.
