Secondary metabolites from Epicoccum nigrum 14one,an endophytic fungus isolated from plant Leptogium masiaticum.
10.19540/j.cnki.cjcmm.20190426.201
- Author:
Chao YUAN
1
;
Yu-Hua GUO
2
;
Ying-Bo ZHANG
1
;
Xuan HU
1
;
Dan WANG
1
;
Fu-Lai YU
1
;
Gang LI
3
Author Information
1. Tropical Crops Genetic Resources Institute,Chinese Academy of Tropical Agricultural Sciences Danzhou 571737,China Hainan Engineering Research Center for Blumea balsamifera Danzhou 571737,China.
2. Shandong Drug and Food Vocational College Weihai 264210,China.
3. Department of Natural Medicinal Chemistry and Pharmacognosy,School of Pharmacy,Qingdao University Qingdao 266021,China.
- Publication Type:Journal Article
- Keywords:
Epicoccum nigrum;
antibacterial activity;
endolichenic fungus;
secondary metabolites
- MeSH:
Ascomycota/chemistry*;
Endophytes/chemistry*;
Magnetic Resonance Spectroscopy;
Microbial Sensitivity Tests;
Secondary Metabolism
- From:
China Journal of Chinese Materia Medica
2019;44(18):4021-4025
- CountryChina
- Language:Chinese
-
Abstract:
Phytochemical investigation of the culture of Epicoccum nigrum,an endolichenic fungus inhabiting Leptogium masiaticum,led to the isolation of 11 compounds. Based on NMR spectroscopy and HRESIMS data,their structures were determined as one alkaloid fusaricide( 1),and seven benzofuran derivatives including epicoccone( 2),4,6-dihydroxy-5-methoxy-7-methyl-1,3-dihydro isobenzofuran( 3),5-methyl-epicoccone B( 4),3,6,7-trihydroxy-5-methoxy-4-methylisobenzo furan-1( 3 H)-one( 5),3-methoxyepicoccone B( 6),2,3,4-trihydroxy-6-( hydroxymethyl)-5-methylbenzyl-alcohol( 7),and isoochracinic acid( 8),together with three epicoccolide analogs epicocconigrones A( 9),epicoccolide B( 10),and epicocconigrones B( 11). Compounds 1,9 and 10 showed potent microorganism inhibitory effects. These results indicated the potential perspective of this endophytic fungus as an eco-friendly biocide.
