Research advance in chemical compounds,pharmacological action and clinical application of Dengzhan Shengmai Capsules.
10.19540/j.cnki.cjcmm.20190629.306
- Author:
Xue-Mei MU
1
;
Nan MI
1
;
Xian-Peng ZU
2
;
Ji YE
2
;
Pei-Ming YANG
1
;
Wei-Dong ZHANG
3
Author Information
1. State Key Laboratory of New Drug and Pharmaceutical Process,China State Institute of Pharmaceutical Industry Shanghai 201203,China.
2. College of Pharmacy,the Second Military Medical University Shanghai 200433,China.
3. State Key Laboratory of New Drug and Pharmaceutical Process,China State Institute of Pharmaceutical Industry Shanghai 201203,China College of Pharmacy,the Second Military Medical University Shanghai 200433,China.
- Publication Type:Review
- Keywords:
Dengzhan Shengmai Capsules;
chemical constituents;
ischemic cardiovascular and cerebrovascular diseases;
pharmacological effects
- MeSH:
Drugs, Chinese Herbal/pharmacology*;
Erigeron/chemistry*;
Humans;
Medicine, Chinese Traditional;
Ophiopogon;
Panax;
Phytochemicals/pharmacology*;
Phytotherapy;
Schisandra
- From:
China Journal of Chinese Materia Medica
2019;44(18):3917-3923
- CountryChina
- Language:Chinese
-
Abstract:
Dengzhan Shengmai Capsules( DZSMC),a well-known traditional Chinese medicine( TCM) formula,is comprised of the main drug of Erigeron breviscapus,and supplemented with Panax ginseng,Ophiopogon japonicus and Schisandra chinensis,with functions of supplementing Qi and nourishing Yin,promoting blood circulation and strengthening brain. DZSMC is the only Chinese patent drug with A-level evidence-based medicine in secondary prevention for stroke and ranks first among TCMs for neurological treatment. Modern studies indicate that the chemical constituents of DZSMC mainly include flavonoids,phenolic acids,lignans,saponins and so on. Pharmacological experimental studies have shown that DZSMC has such pharmacological effects as anti-oxidation,anti-inflammatory and anti-myocardial ischemia. DZSMC is mainly used in the convalescent care of ischemic cardiovascular and cerebrovascular diseases,and is often used in combination with various conventional therapeutic drugs to exert clinical efficacy through brain protection,neuroprotection,etc.,and improve clinical symptoms in patients. In this review,according to domestic and international related literature combined with research results obtained by our project,the research advances in the chemical constituents,pharmacological effects and clinical application of DZSMC have been systematically reviewed and summarized,providing reference and support for further study and secondary development of the formula.
