Research status of common processing technology of traditional Chinese medicine "maintaining medicinal properties after carbonisatus" and supramolecular "imprinting template" characterization technology.
10.19540/j.cnki.cjcmm.20190522.303
- Author:
Yi-Qun ZHOU
1
;
Rui LI
1
;
Yu-Ting HE
1
;
Mei-Feng XIAO
1
;
Yan-Tao YANG
1
;
Wen-Long LIU
1
;
Ji-Lian SHI
1
;
Fu-Yuan HE
1
Author Information
1. College of Pharmacy,Hunan University of Chinese Medicine Changsha 410208,China Hunan Provincial Key Laboratory of Drugability and Preparation Modification of traditional Chinese medicine Changsha 410208,China Laboratory of Supramolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medica,Hunan University of Chinese Medicine Changsha 410208,China.
- Publication Type:Journal Article
- Keywords:
Maintaining medicinal properties after carbonisatus;
imprinting template;
supramolecules;
traditional Chinese medicine processing
- MeSH:
Drugs, Chinese Herbal;
Medicine, Chinese Traditional;
Records;
Reference Standards;
Technology
- From:
China Journal of Chinese Materia Medica
2019;44(19):4293-4299
- CountryChina
- Language:Chinese
-
Abstract:
Based on the characteristics of biological supramolecules and the law of " imprinting template",the research status and common problems in " maintaining medicinal properties after carbonisatus" in traditional Chinese medicine( TCM) were analyzed,and the further countermeasures were put forward. According to the historical evolution of " maintaining medicinal properties after carbonisatus" in TCM processing,the origin of its common problems was clarified by using the theory of biosupramolecular chemistry. TCM is a megacomplex biological supramolecular system,so TCM processing is just the processing of megacomplex biological supramolecular system,and its essence is a TCM pharmaceutical technology with chemical changes in host and guest of biological supramolecular system with or without adjuvant material under high temperature and humidity. In this study on pharmaceutical technology,host molecule was destructed in the process of carbonizing,but guest molecule was retained. The changing law of the host and guest molecule was controlled by the " imprinting template",which was reflected in the degree of change in the drug properties and efficacy of the decoction pieces. Supramolecular chemistry ran through the whole process,and the " imprinting template" of charcoal medicine was characterized by the supramolecular topological structure characteristics and imprinting behavior. After being combined with the quantitative mathematical model of heating degree in processing,it can realize the accurate processing of " maintaining medicinal properties after carbonisatus" from the source,quantitatively control the quality of carbonic herbs,and formulate stable and controllable quality standards.
