Investigation on seco-prezizaane sesquiterpenes from fruits of Illicium lanceolatum and their neuroprotection activity.
10.19540/j.cnki.cjcmm.20190520.201
- Author:
Yang-Lan LIU
1
;
Wen-Rui LI
1
;
Jian-Pei ZHANG
1
;
Jin-Yao YONG
1
;
Dan ZHANG
1
;
Shuang-Gang MA
1
Author Information
1. Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050,China.
- Publication Type:Journal Article
- Keywords:
Illicium lanceolatum;
neuroprotection activity;
seco-prezizaane sesquiterpenes
- MeSH:
Fruit;
Illicium;
Magnetic Resonance Spectroscopy;
Molecular Structure;
Neuroprotection;
Sesquiterpenes
- From:
China Journal of Chinese Materia Medica
2019;44(19):4207-4211
- CountryChina
- Language:Chinese
-
Abstract:
Ten seco-prezizaane sesquiterpenes were isolated from the water-soluble fraction of the fruit of Illicium lanceolatum using the combined methods of silica gel column chromatography,Sephadex LH-20 column chromatography,and RP-preparative HPLC. They were elucidated as majusanol E( 1),2α-hydroxycycloparviflorolide( 2),2β-hydroxy-3,6-dedioxypseudoanisatin( 3),majusanol A( 4),merrillianone( 5),cycloparvifloralone( 6),3α-hydroxycycloparvifloralone( 7),1,2-dehydrocycloparvifloralone( 8),henrylactone C( 9),and( 11) 7,14-ortholactone-3α-hydroxyfloridanolide( 10) according to the NMR data. All compounds were obtained from this plant for the first time. Neuroprotection activity,anti-Coxsackie B3 virus,and anti-H3 N2 virus experiments were carried out to test their bioactivities. The bioassay results showed that compounds 1,4,6,7,9 and 10 displayed weak protective effects of the damage of nerve SH-SY5 Y cell induced by monosodium glutamate.
