A new cytotoxic flavone from Cassia nomame.
- Author:
Ling-Min LIAO
1
;
Yan-Qi SUN
1
;
Qian GAO
2
;
Yin-Ke LI
1
;
Jing LI
2
;
Xin LIU
2
;
Xue-Mei LI
2
;
Guang-Yu YANG
1
;
Yan-Qing YE
3
;
Jian-Gang LI
4
;
Qiu-Fen HU
3
Author Information
- Publication Type:Journal Article
- Keywords: Cassia nomame; cytotoxicity; flavone
- MeSH: Cassia; Chromatography, High Pressure Liquid; Flavones; Humans; MCF-7 Cells; Senna Plant
- From: China Journal of Chinese Materia Medica 2019;44(19):4203-4206
- CountryChina
- Language:Chinese
- Abstract: A new flavone( 1) has been isolated from the whole plant of Cassia nomame by using various chromatographic techniques,including silica gel,Sephadex,MCI-gel resin,and RP-HPLC,and its structure was determined as 8,4'-dimethoxy-7-( 2-oxopropyl)-flavone based on spectroscopic data. The biological activity test showed that this compound displayed potent cytotoxicity against NB4,SH-SY5 Y,PC3,A549 and MCF-7 cell lines with IC50 values 2. 2,1. 8,3. 4,4. 5 and 1. 6 μmol·L-1,respectively.
