Analysis on mechanism of toxicity reduction through compatibility of Aconiti Lateralis Radix Praeparata-Glycyrrhizae Radix et Rhizoma from in vitro component changes,in vivo metabolism and biological effects antagonism.
10.19540/j.cnki.cjcmm.20190701.404
- Author:
Li-Na MA
1
;
Zu-Guang YE
2
;
Guang-Ping ZHANG
2
Author Information
1. Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China Post-doctoral Scientific Research Center,China Academy of Chinese Medical Sciences Beijing 100700,China.
2. Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China.
- Publication Type:Journal Article
- Keywords:
Aconiti Lateralis Radix Praeparata;
Glycyrrhizae Radix et Rhizoma;
biological antagonism;
compatibility attenuation;
couplet medicines;
metabolism in vivo
- MeSH:
Aconitum;
Drugs, Chinese Herbal;
Humans;
Medicine, Chinese Traditional;
Rhizome;
Triterpenes
- From:
China Journal of Chinese Materia Medica
2019;44(19):4165-4170
- CountryChina
- Language:Chinese
-
Abstract:
Aconiti Lateralis Radix Praeparata and Glycyrrhizae Radix et Rhizoma is a representative acid-alkali drug pair,commonly used in clinical application of traditional Chinese medicine( TCM). Its unique compatibility connotation fully embodied the wisdom of ancient people in drug use. In order to more comprehensively and deeply understand the scientific connotation of the compatibility of the two drugs,pharmacy workers have studied the mechanism of reducing toxicity and enhancing efficacy through their compatibility from the perspectives of chemistry,pharmacology and toxicology. On the basis of combing the previous research work,this paper interpreted the unique compatibility connotation from the three-level system of reducing the content of toxic components in vitro by hydrolysis,lipid exchange and formation of associations,the active constituents of Glycyrrhizae Radix et Rhizoma affecting the metabolism of toxic components and direct antagonism of the toxic effects of aconite in vivo. The existing problems and controversies of the modern mechanism of their compatibility were also proposed,providing a reference for further in-depth studies.
